Supplements

Vitamin mineral probiotic drink; sponsor; promoted as a comprehensive supplement; offers with subscription deals.

Hormone signaling light exposure; endogenous production varies with seasons; supplements are often supra-physiological and require caution, especially during pregnancy.

Stimulant discussed as increasing dopamine modestly and influencing receptor density; includes yerba mate as a related caffeine source.

Sponsor with a library of single-ingredient supplements; discussed as high-purity, precise dosages and modular protocols.

A crucial vitamin easily corrected; essential for immune function, brain function, and cancer prevention.

Mentioned as a classical psychedelic acting on the serotonin 5-HT2A receptor.

A mineral essential for over 300 enzymes, including DNA repair, with about half the country not getting enough from their diet.

A supplement taken by Dr. Patrick at 10 grams per day in the morning.

A form of Vitamin D that, when used as a supplement, was associated with a 37% lower risk of dementia.

An amino acid found in green tea that synergizes with caffeine to enhance cognitive performance, attention, and reaction time while reducing anxiety and jitters. It promotes calm, attentive states by increasing GABA and glycine signaling.

Nicotinamide adenine dinucleotide; metabolic cofactor mentioned in the context of alcohol metabolism and longevity.

A dietary amino acid precursor to dopamine mentioned as a purchasable supplement to boost dopamine.

Important fats (DHA/EPA) for fetal brain development; can be consumed via fatty fish or supplements if dietary intake is low.

A vitamin taken by Dr. Patrick at night.

Zero-sugar electrolyte drink; sponsorship shout-out with link Drinkelement.com/lex.

Natural non-caloric sweetener discussed as acceptable; does not raise glucose.

Choline-containing nootropic discussed as a potential cognitive enhancer.

Widely studied supplement discussed as a potent aid for strength and hypertrophy; typical dosing around 5 g/day.

One component of omega-3 fatty acids; mentioned as beneficial for brain health and mood.

A form of magnesium developed to more readily cross the blood-brain barrier, showing promise for improving cognition in small human studies, but should be combined with other forms for systemic benefits.

species of plant

chemical compound

genus of flowering plants

Nutrient pair highlighted as important for hormone and cardiovascular health; included in AG1 offer.

tropane alkaloid and stimulant drug

Plant-based caffeinated beverage; discussed for its modest dopaminergic effects and receptor upregulation properties.

An all-in-one nutritional insurance supplement, recommended by the host in 'The 4-Hour Body' and used for travel and optimal performance.

class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine

antiparasite medication

An essential branched-chain amino acid not made by the body, critical for muscle protein synthesis. Highest quality protein sources are rich in leucine, like whey protein.

polyphenol with a stilbene skeleton

A vitamin supplement offered as a year's supply with Athletic Greens purchase.

A substance that, like other potent drugs, significantly decreases dopamine transmission in the brain's reward pathway in addicted individuals, even after two weeks of abstinence.

agency of the State of Texas, United States

An off-patent drug that Bret Weinstein claims was suppressed but was actually highly effective in treating COVID-19 if administered early, in sufficient quantities.

A compound that some people find helps with sleep, though its effects vary individually, with some experiencing negative outcomes.

Used judiciously for immune support, especially during travel or high stress; high doses (e.g., 1g) can help prevent respiratory infections without significantly blunting long-term adaptations if timed correctly.

sclerotium of the chaga mushroom

chemical compound: amide form of vitamin B3

Another omega-3 fatty acid component; discussed in the context of brain health.

edible mushroom

quaternary ammonium cation

chemical data page

edible mushroom

Herbal extract (Indonesian variety cited as most potent) reported to increase free testosterone (lower SHBG) and libido in some populations; commonly taken as 400 mg/day.

chemical compound

chemical compound

chemical element with symbol Zn and atomic number 30

chemical compound, nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose and is precursor to NAD⁺

a neurotoxic substance releasing extreme amounts of dopamine and norepinephrine in consumed

chemical compound

chemical compound

chemical compound

High-quality protein supplement; described as a preferred protein source; considered minimally processed relative to many others.

chemical element with symbol K and atomic number 19

protein-coding gene in the species Caenorhabditis elegans

5-Hydroxytryptophan, a precursor to serotonin, used for supplementation after psychedelic journeys.

chemical compound, main yellow-orange-colored pigment and active principle of turmeric or curcuma

chemical compound

any organic compound in which the hydroxyl functional group (–OH) is bound to a saturated carbon atom

scientific article published on May 1, 1975

class of drugs used to lower cholesterol levels

scientific article

chemical compound

class of psychoactive drugs

chemical compound

chemical compound

An herb mentioned as being used for vitality and hormone support.

A ketone supplement described as a game changer; featured as a sponsor product with an affiliate link.

species of plant

A spice with anti-inflammatory properties due to its phytochemical curcumin, which blocks certain pro-inflammatory cytokines.

Listed as a tier two supplement alongside melatonin.

peptide hormone found in Homo sapiens

sclerotium of the chaga mushroom

A raw material the body needs to manufacture hormones; supplementing can help balance hormone levels, especially testosterone.

An adaptogen that can reduce fatigue and enhance muscular endurance, possibly by mitigating the stress response.

A supplement that increases blood flow to the brain, recommended for brain health.

A common bioavailable form of Magnesium.

An amino acid that can become neurotransmitters like dopamine, correlating with mood and mental health.

An old dye, not monetized, that serves as a powerful brain energizer by facilitating mitochondrial fuel movement; it literally dyes the brain blue upon consumption, indicating it targets brain cells effectively. Used to treat malaria; taken for brain supercharge.

Another NAD+ precursor and 'NAD+ booster'. Animal studies suggest health benefits in metabolic health, heart function, and cognition. A study also showed it accelerated cancer growth in a specific context.

A regenerative and anti-inflammatory peptide available over-the-counter, mentioned as an example of therapeutic peptides outside of pharmaceutical control.

Distinguished from 'narcotics' to emphasize their medical use in managing pain and shortness of breath at the end of life, despite cultural biases related to addiction.

A supplement mentioned as having limited research compared to the extensive literature on mindfulness.

A drug that blocks glucose absorption, identified by the ITP as targeting glucose metabolism and extending lifespan.

Medium-chain triglyceride oil discussed as a coffee additive to stabilize blood sugar.

A supplement mentioned as potentially improving insulin sensitivity.

A chemical in the body that helps clean up metabolic waste generated by too much exercise; its production is a rate-limiting step.

A ketone supplement that increases blood ketones, used by the speaker for extended focus and energy during cognitive tasks or workouts without needing to eat.

Baking soda, acts as an acute fatigue buffer by making the body more alkaline; can cause GI distress but can be applied topically as a cream.

Byproducts of mitochondrial dysfunction that can cause cellular damage and are increased when mitophagy is inhibited.

An opioid medication commonly used for pain and symptom management at the end of life, with clarification provided to patients about its safe and non-euthanizing use.

A powerful antioxidant that, when supplemented in high doses, can potentially blunt exercise adaptations, especially when combined with Vitamin C.

An older nitric oxide precursor that has fallen out of favor due to bioavailability issues and potential side effects like cold sores; used for blood pressure.

Mentioned as one of the raw materials whose price increase contributed to the rise in battery prices for electric vehicles.

organic cation

Nicotinamide riboside; discussed in the NAD-related longevity discussion.

An herbal supplement that may impact intra-testicular antioxidant activity, potentially improving local hormone yield, but requires careful sourcing.

A toxic chemical commonly used in gold mining operations that seeps into waterways and pollutes local ecosystems.

Used as an alternative to penicillin in some parts of the world due to its antibiotic and antiseptic properties. Raw garlic is a powerful prebiotic, aiding gut flora. Can perform a 'garlic intensive' for low-level infections.