Betaine
A supplement mentioned as having limited research compared to the extensive literature on mindfulness.
Common Themes
Videos Mentioning Betaine

Tools for Hormone Optimization in Males | Dr. Kyle Gillett
Andrew Huberman
A supplement, often mixed with creatine, that helps with amino acid synthesis and energy shunting, particularly useful for creatine non-responders or those with elevated homocysteine, taken at 1-3 grams per day.

The Science of Eating for Health, Fat Loss & Lean Muscle | Dr. Layne Norton
Andrew Huberman
Also known as trimethylglycine, with some evidence suggesting it can improve lean mass and power output.

Betaine, Sodium Bicarbonate, and Evaluating New Research as it Develops (Episode 45)
Stronger By Science
A supplement discussed for its potential effects on body composition (increased meat yield, reduced subcutaneous fat in pigs; promising human studies with training) and performance (mixed, inconsistent results in short-term human studies). It is considered safe and well-tolerated.

Cell Swelling, Genetic Ceilings, Touch-and-Go Deadlifts, and Load-Specific Adaptations (Episode 34)
Stronger By Science
Mentioned as an osmolytic supplement that can increase fluid volume within the muscle, potentially relevant to muscle performance.
![[AUDIO FIXED] Glycogen Loading, Lower Back Pain, PowerBuilding, & Physical Culture with Ben Pollack](https://i.ytimg.com/vi/9rqE02_gAkw/maxresdefault.jpg)
[AUDIO FIXED] Glycogen Loading, Lower Back Pain, PowerBuilding, & Physical Culture with Ben Pollack
Stronger By Science
An ingredient supposedly in Biotest's 'Plasma' product, but its dosage is unknown due to proprietary blending.

Q&A: Bands, Chains, Useful Supplements, and Tweaking Your Program (Episode 27)
Stronger By Science
Derived from beets, spinach, and seafood. Has some modest, measurable fat loss benefits in resistance-trained individuals, though performance and lean mass effects are less impressive.

Body Composition Assessments & Fitness-Related Applications of Mindfulness and Meditation (Ep 100)
Stronger By Science
A supplement mentioned as having limited research compared to the extensive literature on mindfulness.

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)
Stronger By Science
A meta-analysis on betaine's effect on adiposity showed results primarily driven by two studies, highlighting the need for caution when interpreting meta-analyses with limited data.

Sex Differences in Fatigue and Recovery, and Dr. Jason Cholewa (Podcast Episode 2)
Stronger By Science
Also known as trimethylglycine, this compound was the focus of Dr. Jason Cholewa's dissertation and is discussed for its potential effects on strength, body composition, and performance.