Berberine
quaternary ammonium cation
Common Themes
Videos Mentioning Berberine

Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep
FoundMyFitness
A supplement widely recognized for its effectiveness in improving insulin sensitivity.

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
Andrew Huberman
A compound that lowers blood glucose and impacts mTOR; Huberman avoids it due to causing severe headaches.

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects
Andrew Huberman
A substance derived from tree bark, sometimes referred to as the 'poor man's Metformin' due to its similar properties of reducing mTOR and blood glucose.

The Science of Healthy Hair, Hair Loss and How to Regrow Hair
Andrew Huberman
A substance from tree bark known as 'the poor man's Metformin' that potently improves insulin sensitivity by dramatically reducing blood sugar levels.

Developing a Rational Approach to Supplementation for Health & Performance | Huberman Lab Podcast
Andrew Huberman
A supplement-based approach to reducing blood glucose, which can indirectly affect sex hormone binding globulin and free testosterone.

The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman
A substance from tree bark, known as 'the poor man's Metformin,' that boosts energetics like AMPK and Metformin, increases insulin sensitivity, but may not extend worm lifespan.

Tools for Hormone Optimization in Males | Dr. Kyle Gillett
Andrew Huberman
A compound that can slightly decrease TMAO conversion and has other effects on blood sugar, potentially causing headaches and carbohydrate cravings in some individuals.

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41
Andrew Huberman
An over-the-counter substance with effects almost identical to Metformin, leading to dramatic reductions in blood glucose. Caution is advised due to potential side effects like hypoglycemia and headaches.

The Science of Eating for Health, Fat Loss & Lean Muscle | Dr. Layne Norton
Andrew Huberman
A glucose scavenger sometimes used as a 'carb blocker,' but its overall impact on weight loss is considered minor, and it can cause side effects like headaches.

How to Lose Fat with Science-Based Tools
Andrew Huberman
A compound derived from a plant, used to reduce blood glucose and subsequently insulin levels, which facilitates fat oxidation.

Controlling Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Podcast #64
Andrew Huberman
A potent derivative of tree bark that effectively reduces blood glucose, comparable to prescription drugs like Metformin or Glibenclamide, but requires caution due to potential hypoglycemia.

How Our Hormones Control Our Hunger, Eating & Satiety
Andrew Huberman
A non-prescription compound derived from plants and tree bark, often compared to Metformin due to its strong effects in lowering blood glucose and cholesterol, activating the AMPK pathway. Andrew Huberman experienced headaches and severe hypoglycemia from it.

AMA #3: supplements, women’s health, patient care, and more (EP.26) | The Peter Attia Drive
Peter Attia MD
A plant-derived extract that acts as a weak AMPK activator and PCSK9 inhibitor; used by Attia for patients with high LDL particle numbers. Recommended brand: Thorne.

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda
Andrew Huberman
A tree bark extract that dramatically lowers blood glucose, often called 'the poor man's Metformin,' but can cause hypoglycemia if not taken with carbohydrates.

Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!
The Diary Of A CEO
A natural equivalent to Metformin, also activating the AMPK pathway for longevity benefits; Dr. Sinclair recommends pulsing it.