Controlling Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Podcast #64

An all-in-one vitamin, mineral, and probiotic drink that Andrew Huberman has been taking since 2012 to cover basic nutritional needs and support microbiome health.

A personalized nutrition platform that analyzes blood and DNA data to provide insights and actionable directives for lifestyle, nutrition, and supplementation.

A combination of vitamins offered with Athletic Greens, where D3 is essential for brain/body health, and K2 regulates cardiovascular function and calcium.

An amino acid that can be supplemented (several grams per day) to potentially blunt sugar cravings and support gut health, including addressing leaky gut.

Essential fatty acids, particularly the EPA form, shown to be beneficial for people with ADHD and can rival or reduce the need for prescription antidepressants, as well as support heart health.

A substance known to augment the effects of Berberine via the AMPK pathways, increasing its glucose-lowering actions.

A phospholipid mentioned as an ingredient in Thesis nootropics.

A hormone that increases with time since the last meal, stimulating hunger by interacting with neurons in the hypothalamus, and is suppressed upon eating.

A herbal supplement mentioned as an ingredient in Thesis nootropics.

A potent derivative of tree bark that effectively reduces blood glucose, comparable to prescription drugs like Metformin or Glibenclamide, but requires caution due to potential hypoglycemia.

A flavorless substance that increases blood glucose, used in studies to condition flavor preferences and insulin responses.

An omega-3 fatty acid mentioned as an ingredient in Thesis nootropics.

The podcast where science and science-based tools for everyday life are discussed, hosted by Andrew Huberman.

Publisher of the journal 'Neuron' and 'Cell Report', highly regarded scientific journals.

Institution of Charles Zuker, whose work on taste pathways showed how different tastes interact in the brain.

Andrew Huberman's affiliation as a professor of neurobiology and ophthalmology.

The institution where Dr. Robert Lustig works as a pediatric endocrinologist.

Researcher at Yale University whose lab has conducted beautiful neuroimaging studies on how the brain processes food, especially with 2-Deoxy-D-glucose and conditioned taste preference.

Researcher at Columbia Medical School whose work illuminated how sweet and sour tastes co-ingested lead to distinct neural activity patterns.

Author of 'The 4-Hour Body' and 'The 4-Hour Chef', credited with being ahead of his time in nutrition and skill learning, and for experimenting with methods like vinegar ingestion for glucose control.

Host of the Huberman Lab Podcast and a professor of neurobiology and ophthalmology at Stanford School of Medicine.

A phenomenal colleague from Stanford School of Medicine and an expert on addiction and dopamine pathways, author of 'Dopamine Nation'.

Pediatric endocrinologist at the University of California San Francisco, an early advocate against hidden sugars and highly processed foods, whose work showed the benefits of replacing fructose with glucose.

Professor at Duke University who famously discovered neuropod cells.

A book by Tim Ferriss that discussed nutrition and skill-learning concepts, some of which have been scientifically validated.

A journal where a study illustrating the subconscious sugar-seeking circuits was published, with Freeman as the first author.

A book by Dr. Anna Lembke on addiction and dopamine, highly recommended for understanding motivated behaviors and avoiding pitfalls.

A journal that published a meta-analysis on sugar consumption, sugar-sweetened beverages, and ADHD, concluding that refined sugars negatively affect ADHD symptoms.

A scientific journal where related studies on subconscious sugar-seeking circuits have been published.

A book by Tim Ferriss that discussed nutrition and skill-learning concepts, some of which have been scientifically validated.

A signaling pathway involved in cell growth and metabolism, which is reduced by substances like Berberine as part of longevity strategies.

A metabolic pathway activated to increase longevity, which Berberine and sodium caprate are thought to influence.

A highly concentrated form of fructose (around 50% or more) that is deemed detrimental to health, especially in large consumption.

A nerve pathway involved in communication from gut neuropod cells to the brain, influencing dopamine release and appetite.

A type of sugar found in fruit and high fructose corn syrup, which is metabolized differently than glucose and can increase hunger by reducing hormones that suppress Ghrelin.

The most abundant cell type in the brain, responsible for delivering glucose to neurons and critically involved in shaping neuronal function and brain plasticity.

Neurons within the gut that respond to the presence of sugar, amino acids, and essential fatty acids, sending electrical signals to the brain via the vagus nerve to trigger dopamine release and increase appetite.

A Cell Press journal where a study on neuronal tuning and blood glucose levels was published.

An artificial sweetener that, at high doses in animal studies, has been shown to disrupt the gut microbiome.

A Cell Press journal where a study on sleep stages and metabolism was published, showing distinct metabolic signatures during different sleep phases.

Devices like Levels that monitor blood glucose in real-time, allowing individuals to see how different foods and activities affect their blood sugar.

A nootropics company that creates targeted nootropics for specific outcomes, using high-quality ingredients like DHA, Ginkgo biloba, and phosphatidylserine.

A prescription drug used to reduce blood glucose, mentioned as being on par with Berberine in potency.

A prescription drug used to reduce blood glucose, mentioned as being on par with Berberine in potency.

A neurodevelopmental disorder where sugar consumption, especially refined sugars, is generally considered detrimental to symptoms and attention.

A laboratory tool used to block glucose uptake from neurons, which also helps to reveal the neural pathways involved in sweet food preference, independent of taste perception.