Phosphatidylserine
class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine
Research
Common Themes
Videos Mentioning Phosphatidylserine

World No.1 Sleep Expert: Magnesium Isn’t Helping You Sleep! This Habit Increases Heart Disease 57%!
The Diary Of A CEO
A compound that helps by ratcheting down the fight-or-flight nervous system and reducing cortisol, beneficial for individuals experiencing high stress before bed.

#48–Matt Walker, Ph.D., on Sleep (Part 2 of 3): Heart disease, cancer, causes of sleep disruption...
Peter Attia MD
A supplement that, at doses of 400-600mg, anecdotally helps mitigate high nighttime cortisol and glucose responses, particularly in jet lag scenarios, by addressing the endocrine system's stress response.

Q&A with Tim — Exercise And Morning Routines, Holotropic Breathwork, and More | The Tim Ferriss Show
Tim Ferriss
A supplement recommended for individuals whose minds remain active when trying to sleep, and also for lowering cortisol levels.

The Science of Love, Desire and Attachment
Andrew Huberman
An ingredient used in Thesis nootropics, also used on occasion by the host.

How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Andrew Huberman
A supplement effective in modestly reducing cortisol, with a typical effective dose of 400-800mg, and can be taken in the morning or at night depending on cortisol patterns.

Science of Mindsets for Health & Performance | Dr. Alia Crum
Andrew Huberman
An ingredient mentioned in Thesis nootropic formulations.

Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman
Andrew Huberman
A phospholipid mentioned as an ingredient in Thesis nootropics, discussed in the context of ADHD.

Nutrients For Brain Health & Performance | Huberman Lab Podcast #42
Andrew Huberman
A lipid-like compound abundant in meats and fish, shown in studies to modestly improve cognition and reduce cognitive decline; a common supplemental dosage is 300 milligrams per day.

Science-Based Tools for Increasing Happiness
Andrew Huberman
An ingredient used in Thesis nootropics, mentioned as a high-quality ingredient discussed on the podcast.

Focus Toolkit: Tools to Improve Your Focus & Concentration
Andrew Huberman
A nootropic ingredient mentioned in Thesis formulas, beneficial for cognitive function.

Understand & Improve Memory Using Science-Based Tools
Andrew Huberman
A nootropic ingredient used in Thesis blends, mentioned for its potential to enhance learning and memory.

Micronutrients for Health & Longevity | Dr. Rhonda Patrick
Andrew Huberman
An ingredient mentioned in Thesis nootropics, known for its role in brain health.

#59–Jason Fung, M.D: Fasting as an antidote to obesity, insulin resistance, T2D, & metabolic illness
Peter Attia MD
A supplement recommended to patients during fasting to calm adrenal glands and reduce sympathetic outflow, aiding sleep.

#56–Jocko Willink Part 2 of 2: Sleep, fasting, kids, discipline, ownership, & the impact of war
Peter Attia MD
A supplement Peter Attia uses in conjunction with Kirk Parsley's supplement to achieve deep, intense sleep while fasting.

Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance
Andrew Huberman
Ingredient found in Thesis nootropics, a phospholipid often studied for its role in brain health.

Controlling Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Podcast #64
Andrew Huberman
A phospholipid mentioned as an ingredient in Thesis nootropics.

Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming | Huberman Lab Guest Series
Andrew Huberman
Supplement with good data supporting its ability to tamp down the cortisol response, potentially helpful for insomnia patients experiencing cortisol spikes before or during sleep.

221 ‒ Understanding sleep and how to improve it
Peter Attia MD
A supplement used by Peter Attia as part of his jet lag protocol.

256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.
Peter Attia MD
A phospholipid supplement that has been shown to suppress evening cortisol production, aiding in sleep regulation and managing stress responses.

Blake Mycoskie — TOMS, Conscious Uncoupling, and Psychedelics | The Tim Ferriss Show
Tim Ferriss
A supplement Tim Ferriss sometimes takes before bed to help blunt cortisol response, particularly when feeling 'tired and wired'.