Drugs & Medications

Psychedelic compound discussed in the context of MRI studies; relates to the psilocybin/psilocin administration in subjects.

empathogen and stimulant

Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.

Lysergic acid diethylamide; discussed as part of psychedelic history and MKUltra-era discourse.

A legal substance used in therapy, intriguing due to its similar effects to psilocybin and MDMA despite being chemically different.

Psychoactive brew discussed in Brooklyn anecdote and personal experience; described as introspective and transformative.

Mentioned as a candidate drug for extending healthspan, part of the longevity interventions Jamie discusses.

ADHD medication, mentioned for its side effects but also highlighting the serious consequences of untreated ADHD.

Selective serotonin reuptake inhibitors, a class of antidepressant drugs, linked to a 75% increased risk of dementia in a meta-analysis of five studies.

A powerful opioid mentioned as a substance that addiction psychiatrist Dr. K helps patients overcome using meditation and other therapies.

A GLP-1 agonist drug used for weight loss and type 2 diabetes management.

Discussed in contrast to cocaine; its mechanism for keeping people awake is not classically stimulant-like and differs from cocaine's action.

Another psychedelic that has been explored for opioid use disorder, though studies have been less promising compared to psilocybin.

A medication for ADHD, described as a 'speed' (amphetamine), but noted for its effectiveness in increasing prefrontal cortex size and improving outcomes for children with ADHD.

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

Mentioned as an example of a common drug to which some people can have extreme individual responses, illustrating the variability in drug side effects.

chemical compound

Lipid-lowering medications that can increase the risk of type 2 diabetes by 50% in middle-aged and older women and may harm mitochondria.

GLP-1 receptor agonist used for diabetes and obesity; long-acting variants lead to sustained appetite suppression; approved 2005 (diabetes) and 2014 (obesity).

chemical compound

A psychedelic tryptamine, a serotonin agonist, known for inducing profound and rapid shifts in consciousness, leading to a sense of ego dissolution and intense, overwhelming experiences.

Mentioned as a major advance in healthcare that most people in the US have access to.

chemical compound

Mentioned as a psycho-stimulant but warned against due to its high addictive potential, especially in contrast to caffeine.

A stimulant medication that can be used to treat bulimia and binge eating disorder by increasing dopamine and norepinephrine.

An antidepressant that increases dopamine, used off-label to help men and women increase libido or sexual function.

pharmaceutical preparation of the element lithium, used primarily as a psychiatric medication for mood disorders

pharmaceutical product

Wikimedia disambiguation page

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

Another prostaglandin inhibitor, shown to have modest protective effects against autism-like symptoms in animal studies and a 13% relative risk reduction in the Swedish cohort study, which argues against acetaminophen's causal link.

Drug class discussed as potential brain health modulators; evidence discussed is preliminary.

agents that inhibit Proprotein Convertase Subtilisin/Kexin Type 9, an enzyme that plays a role in the degradation of the LDL cholesterol receptors

Glucagon-like peptide-1 hormone; the natural signal that GLP-1 drugs aim to mimic to reduce appetite and regulate appetite-related hormones.

Another GLP-1 agonist medication similar to Ozempic, used for obesity.

A benzodiazepine (Web 1.0 sleep medication) not considered great for sleep, as it primarily sedates rather than induces naturalistic sleep.

A 5-alpha reductase inhibitor drug used to treat androgenic alopecia by inhibiting DHT production, but comes with potential side effects.

chemical compound and antiviral drug

chemical compound

chemical compound with antipyretic and pain relieving properties

organic compound, often used as a street drug

chemical compound

A class of drugs considered interesting for geroprotection, potentially comparable to rapamycin and GLP-1 agonists. The speaker notes their effect in metabolically healthy individuals is less clear.

neuropeptide analogue of gastric inhibitory polypeptide

chemical compound, antidepressant medication

chemical compound

species of plant

chemical compound

chemical compound

immunomodulatory drug known for its ability to cause birth defects

viral disease affecting humans

Cosmetic treatment mentioned as a way to counter resting sad/frowned facial cues during interactions.

A prodrug that inhibits cholesterol synthesis specifically in the liver, leading to lower ApoB and LDL cholesterol without the side effects of statins, but it is currently expensive.

A drug that caused significant harm, highlighting the need for post-market surveillance.

A GLP-1 agonist drug used for weight loss and type 2 diabetes management, often at higher doses than other GLP-1 activators.

A more potent 5-alpha reductase inhibitor than finasteride, used for male pattern baldness and benign prostatic hyperplasia, with a similar side effect profile to finasteride.

A statin medication mentioned by Stuart McGill as something his doctor considered prescribing for his cholesterol.

Another statin medication mentioned by Stuart McGill as something his doctor considered prescribing.

An opioid pain medication Peter became physically dependent on following a back injury, highlighting the rapid onset of physical dependence.

A statin drug mentioned as an example of a pharmaceutical with a similar effect to red yeast rice, used for lowering ApoB.

A major disease that caused widespread death among indigenous populations in the Americas, wiping out an estimated 80% of the population due to lack of immunity.

An over-the-counter pain reliever, mentioned in a hypothetical scenario about managing physical pain and the avoidance of it.

A new treatment approach that stimulates the immune system to track down and kill cancer cells; exercise is described as an 'original immunotherapy'.

A SGLT2 inhibitor drug that has succeeded in the ITP.

An infectious disease that needs better public health attention. Prevention through mosquito nets is presented as a highly cost-effective solution.

A phosphodiesterase-5 inhibitor often prescribed daily at 5mg for psychogenic ED to break the 'vicious cycle' of anxiety, and also for BPH and pulmonary hypertension. It's suggested as a preventative measure for smooth muscle health.

A stimulant drug, both recreational and pharmaceutical (like Adderall), that increases dopamine and norepinephrine, discussed as a treatment for ADHD.

An SSRI antidepressant, juxtaposed with natural alternatives that are shown to be equally effective.

A corticosteroid mentioned as an example, where a dose of 5 mg/day can significantly reduce BMD and increase fracture risk within months.

A banned substance in many countries with reported adverse events, generally not recommended as a fat burner.

A GHRH peptide, often combined with a DAC (drug affinity complex) to extend its half-life.

A phosphodiesterase-5 inhibitor that blocks the enzyme phosphodiesterase, increasing cyclic GMP to maintain erections. It was originally developed as a blood pressure medication.

The antibiotic Dr. Snyder requested and took to treat suspected Lyme disease, which proved effective.

A diviner's sage containing Salvinorin A, which can produce dysphoric out-of-body experiences, studied by the host under clinical settings.

Human Chorionic Gonadotropin, a prescription drug used to increase fertility by stimulating testosterone and estrogen production.

A medication that reduces the risk of breast cancer by 50% over 10 years, offered to patients with a very high lifetime risk (north of 35%).

Measles, mumps, and rubella vaccine, mentioned as not containing Thimerosal in a debate context.

An FDA-approved drug that targets the melanocortin pathway to enhance libido in females. It is injectable and can cause hyperpigmentation in some women.

A pharmaceutical drug that has been studied in conjunction with TMS, relevant for understanding synergistic effects.

A commonly prescribed ester of testosterone for TRT, with a long half-life (around 10 days) that influences injection frequency.

An opioid receptor blocker used to treat alcohol use disorder by making alcohol less reinforcing, and also for opioid addiction.

An antimalarial drug and lysosomal inhibitor that was initially thought to inhibit autophagy in cancer treatment, but its mechanism is broader than just autophagy inhibition.

Cited as an example of a medication that, if taken before bed, could be overly stimulating and disrupt sleep.

A non-feminizing version of estrogen that is being worked on for Blueprint.

Antidepressants that can be used off-label to prolong ejaculatory time, though they may have side effects like reduced libido and ED.

Selective Androgen Receptor Modulators mentioned as an alternative approach to building muscle that did not pan out as hoped by pharmaceutical companies, hinting at potential interest in Follistatin therapies.

An opioid used as a treatment for opioid use disorder, sometimes prescribed to help individuals withdraw from kratom.

A lower-dose formulation of finasteride (1 mg/day) used to treat hair loss.

A medication (Category C) that 'can't be ruled out' for risk during pregnancy, but benefits for the mother may justify its use.

An antihistamine used in Tylenol PM to induce sleep, with concerns raised about forming a bad habit.

A statin where maximum efficacy is achieved at a low dose (e.g., 5mg), with higher doses primarily increasing side effects.

A painkiller mentioned in the context of Josh Peck's struggles with substance use, where drinking alcohol could lead to its use.

An FDA-approved, centrally acting drug for hypoactive sexual desire disorder (HSDD) in premenopausal women, taken daily at bedtime. Works on serotinergic and dopaminergic receptors.

Non-steroidal anti-inflammatory drugs that can blunt exercise adaptations and should not be used routinely to get through training; acceptable for acute, severe pain.

A medication taken during fasting to manage rising uric acid levels, mentioned by the speaker.

Mentioned in the context of placebo studies, where subjects believing they received EPO experienced a large placebo effect on endurance performance.

A statin used in trials for children with heterozygous FH.

An autoimmune condition that Nick Cannon was diagnosed with at 32, specifically lupus nephritis, where his immune system attacks his kidneys.

An immunosuppressant medication, mentioned in the context of its use in hospitals for COVID-19 patients, which could potentially activate clinically silent parasitic infections.

The generic name for Prozac, a selective serotonin reuptake inhibitor (SSRI).