Statins

Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep

FoundMyFitness

Lipid-lowering medications that can increase the risk of type 2 diabetes by 50% in middle-aged and older women and may harm mitochondria.

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

Peter Attia MD

A class of medications that inhibit cholesterol synthesis, primarily known for reducing LDL cholesterol and, indirectly, increasing LDL receptors on the liver.

#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

Peter Attia MD

A class of drugs that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, primarily in the liver, leading to increased LDL receptor expression and ApoB lowering. Noted for their widespread use and ongoing role in lipid-lowering therapy.

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

Peter Attia MD

A class of cholesterol-lowering drugs, mentioned as a benchmark against which PCSK9 inhibitors are compared in terms of cost-effectiveness.

Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More

Tim Ferriss

A class of drugs that inhibit cholesterol synthesis, generally safe and well-tolerated despite public debate, with a hypothesis that their safety comes from naturally occurring origins.

#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more

Peter Attia MD

A class of drugs that lower LDL cholesterol but do not significantly lower Lp(a) particle count.

#23–Tom Dayspring Part IV of V: statins, Zetia, PCSK9 inhibitors, niacin, cholesterol & the brain

Peter Attia MD

Drugs that inhibit HMG-CoA reductase, leading to reduced cholesterol synthesis in the liver and upregulation of LDL receptors, effectively lowering LDL cholesterol and significantly reducing cardiovascular events. Different statins have varying lipophilicity and drug interaction profiles.

Exercise, Nutrition, Hormones for Vitality & Longevity | Dr. Peter Attia

Andrew Huberman

A class of drugs that inhibit cholesterol synthesis in the liver, leading to increased LDL receptor expression and removal of LDL from circulation; generally considered safe with a low side effect profile.

#66 – Vamsi Mootha, MD: Aging, T2D, cancer, dementia, Parkinson’s—do all roads lead to mitochondria?

Peter Attia MD

Drugs that target HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL receptor expression, with broad benefits beyond direct LDL reduction, potentially including anti-inflammatory effects.

253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results

Peter Attia MD

Lipid-lowering medications. 7% of WHI participants were taking statins at the start, increasing to over 25% during the trial.

#07 – Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know

Peter Attia MD

Medications primarily used to lower LDL cholesterol by upregulating LDL receptors in the liver. They generally do not lower Lp(a) but are crucial for managing LDL targets in patients with elevated Lp(a).

How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon

Andrew Huberman

Medications used to lower cholesterol, which can have side effects like muscle pain (myalgia) and deplete CoQ10.

How to Improve Brain Health & Offset Neurodegeneration | Dr. Gary Steinberg

Andrew Huberman

Medications very effective in lowering bad cholesterol (LDL), preventing strokes and heart attacks, and shown to be beneficial for blood vessel integrity even without high LDL.

235‒Training principles for mass & strength, changing views on nutrition, & creatine supplementation

Peter Attia MD

Cholesterol-lowering medication, mentioned by Lane Norton as something he takes a low dose of to manage LDL cholesterol.

Dan Wang on What China and America Can Learn from Each Other

Conversations with Tyler

Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

FoundMyFitness

230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more

Peter Attia MD

Lipid-lowering medications that generally benefit women in both primary and secondary prevention, without sex interaction, but women are often less likely to be offered, more likely to decline/discontinue, and more likely to report muscle symptoms.

Coaching Cues, Fat-Free Mass Index, Non-Responders, and Dr. Brad Dieter (Podcast Episode 10)

Stronger By Science

Medication used for elevated cholesterol, mentioned in the context of standard care for cardiovascular disease, affecting the perceived benefit of new dietary interventions.

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia MD

A class of drugs mentioned as one of the three 'best drugs in the world' (along with Rapamycin and Metformin) with nutraceutical origins, despite being prescription medications.

E110: 2023 Bestie Predictions!

All-In Podcast

Described as a 'clear wonder drug' with unimpeachable 50-year longitudinal data on its value for health.