Niacin
chemical compound: amide form of vitamin B3
Research
Common Themes
Videos Mentioning Niacin
#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology
Peter Attia MD
Historically used for triglyceride lowering, but now considered a 'dead drug' and out of every major guideline due to lack of proven cardiovascular benefit.
#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
Peter Attia MD
A vitamin that can lower Lp(a) to a lesser extent than other methods, though its efficacy is debated in this context.
#23–Tom Dayspring Part IV of V: statins, Zetia, PCSK9 inhibitors, niacin, cholesterol & the brain
Peter Attia MD
A supplement (Vitamin B3) historically used to lower total cholesterol and raise HDL, but its efficacy in reducing clinical events has been problematic in trials, often showing side effects like flushing and worsening insulin resistance, leading to its current limited role in therapy.
#07 – Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know
Peter Attia MD
A vitamin that can lower LDL and raise HDL, and may lower Lp(a) by about a third, though its clinical benefit for Lp(a) patients is debated.
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Peter Attia MD
A drug that effectively raises HDL cholesterol and modestly lowers ApoB, triglycerides, LDL, and Lp(a). Historically used, but large clinical trials showed minimal cardiovascular benefit, leading to its diminished use.
The Psychedelic News Hour - New Breakthroughs, Treatment of Trauma, and More | The Tim Ferriss Show
Tim Ferriss
Mentioned as an 'active placebo' that can create a physiological effect (skin flushing or niacin flush) in psychedelic studies to maintain blinding.
Dr Andrew Weil — Optimal Health, Plant Medicine, and More | The Tim Ferriss Show (Podcast)
Tim Ferriss
A vitamin sometimes used as an active placebo in psychedelic studies.
How Mushrooms Can Save You and (Perhaps) the World — Paul Stamets
Tim Ferriss
A nicotinic acid that Paul Stamets proposes stacking with psilocybin and Lion's Mane to excite nerve endings and drive neurogenesis.
210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.& Peter Attia, M.D.
Peter Attia MD
A drug historically recommended to lower Lp(a), hHDL, and triglycerides, but large outcomes trials showed no cardiovascular benefit and significant side effects.
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
FoundMyFitness
Vitamin B3, found in foods like lean meats and vegetables. Its three forms (nicotinamide, nicotinic acid, nicotinamide riboside) can be used to synthesize NAD+.
230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more
Peter Attia MD
A drug that lowers Lp(a) but has not shown clinical cardiovascular benefit in outcome studies, hence not recommended for Lp(a) lowering.
216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.
Peter Attia MD
A healthy substance and form of vitamin B3, which NR and NMN are primarily converted to upon oral ingestion. High doses can cause a 'flush'.
Sex Differences in Fatigue and Recovery, and Dr. Jason Cholewa (Podcast Episode 2)
Stronger By Science
A supplement that can cause a 'flush' sensation, especially on an empty stomach.
Erik Vance (Full Episode) | The Tim Ferriss Show (Podcast)
Tim Ferriss
A B vitamin that causes a tingling sensation, used as an example of an 'active placebo' in bunk supplements to create the illusion of effectiveness.
Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!
The Diary Of A CEO
Taken by Dr. Sinclair in high doses to reduce LP(a) cholesterol levels, though it can cause flushing and discomfort.