Trazodone

All Things Sleep (Weight Gain, Alzheimer’s Disease, Caffeine, and More) — Dr. Matthew Walker

Tim Ferriss

An antidepressant medication widely prescribed off-label for sleep at lower doses. It works by targeting wake-promoting neurochemical systems (noradrenaline, serotonin, histamine) and appears to increase deep non-REM sleep without disrupting REM sleep, with no significant tolerance build-up observed over a month.

The Random Show — Sobriety, Fasting, Home Defense, Vibe Coding, Roblox, and More

Tim Ferriss

The Science & Treatment of Bipolar Disorder

Andrew Huberman

A medication often prescribed to help people in manic episodes get sleep, working through the GABA system.

How Trauma Works and How to Heal From It — Paul Conti, MD

Tim Ferriss

A sedating medication originally intended as an antidepressant but repurposed for sleep due to its strong sedative effects in most people; safe in appropriate dosing with little to no side effect for many.

How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Andrew Huberman

A sleep supplement that should not be taken daily.

#49–Matt Walker, Ph.D., on Sleep (Part 3 of 3): Effects of poor sleep on metabolism & performance...

Peter Attia MD

A pharmaceutical drug with anti-ruminative properties, mentioned as a 'big gun' that some patients are recalcitrant to for sleep.

202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes

Peter Attia MD

An old-school antidepressant that has emerged as a great, regular maintenance sleep drug for most people at low doses (25-100mg nightly) because it preserves sleep architecture and lacks dependency issues.

Arthur Brooks — Finding The Meaning of Your Life

Tim Ferriss

An early-generation antidepressant repurposed as a sleep aid.

Performance Coach Andy Galpin — Rebooting Tim’s Sleep, Nutrition, Supplements, and Training for 2024

Tim Ferriss

A prescription medication Tim took for sleep issues, with a strong warning that it should not be taken without doctor supervision.

260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it

Peter Attia MD

A medication commonly used as a sleep agent that can, in rare cases, induce priapism (prolonged erection).

Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming | Huberman Lab Guest Series

Andrew Huberman

A medication sometimes used to help people fall asleep, though with some community pushback.