5-MeO-DMT
A psychedelic tryptamine, a serotonin agonist, known for inducing profound and rapid shifts in consciousness, leading to a sense of ego dissolution and intense, overwhelming experiences.
Common Themes
Videos Mentioning 5-MeO-DMT

Michael Pollan — This Is Your Mind on Plants | The Tim Ferriss Show
Tim Ferriss
A powerful psychoactive substance, not a plant, derived from a toad, considered by Michael Pollan as a potential subject for his book.

How to Expand Your Consciousness | Dr. Christof Koch
Andrew Huberman
A psychedelic tryptamine, a serotonin agonist, known for inducing profound and rapid shifts in consciousness, leading to a sense of ego dissolution and intense, overwhelming experiences.

How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks
Andrew Huberman
Another tryptamine psychedelic mentioned alongside DMT and psilocybin.

Dr. Andrew Weil — The 4-7-8 Breath Method, How to Emerge from Depression, & More
Tim Ferriss
A chemical identified in the venom of Bufo alvarius, making it unique among toads and contributing to the spread of its use among hippies.

Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances and More
Tim Ferriss
A psychoactive substance that is more synthetically approachable than ibogaine and is being pursued by several pharmaceutical companies for therapeutic use. It can be synthesized in a one-step reaction.

An Ethnopharmacologist on Hallucinogens, Sex-Crazed Cicadas, and More | Dennis McKenna
Tim Ferriss
A psychoactive substance; some individuals are insensitive to DMT but sensitive to 5-MeO-DMT, highlighting biochemical individuality.

Hamilton Morris on Iboga, 5-MeO-DMT, the Power of Ritual, New Frontiers in Psychedelics, and More
Tim Ferriss
A psychoactive compound, often derived from the Sonoran Desert Toad, which is pharmacologically and تجربely distinct from DMT, inducing near-death like experiences and dissociative effects.

The Case Against Reality — Professor Donald Hoffman
Tim Ferriss
A psychedelic compound mentioned for its distinct subjective experience compared to N,N-DMT, and used systematically by some friends of Hoffman.

Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams
Andrew Huberman
A flavor of DMT, often called 'the Toad' from the Sonoran River toad, used sacramentally and lasting longer than traditional DMT. Used by Navy SEALs after ibogaine in a two-part treatment.

Q&A with Tim — Tools for Better Sleep, Parenting, Fear, How to Boost Your Mood, and More
Tim Ferriss
A powerful psychedelic compound with a short duration, referred to as the 'businessman's high', but can be highly destabilizing and disorienting.

Rick Doblin: Psychedelics | Lex Fridman Podcast #202
Lex Fridman
A toxin from the Sonoran toad, considered one of the most powerful psychedelics, known for completely dissolving ego structures and revealing deeper layers of consciousness.

Psychedelics & Mortality: A Conversation with Roland Griffiths (Episode #306)
Sam Harris
A potent psychedelic compound, mentioned as a distinct type of psychedelic from LSD, psilocybin, and mescaline, suggesting variety in psychedelic experiences.

The Psychedelic News Hour - New Breakthroughs, Treatment of Trauma, and More | The Tim Ferriss Show
Tim Ferriss
A potent psychedelic viewed by some as the 'Everest' of psychedelics, but described here as another tool with a narrower application band.

The Random Show — Zen, Investing, Mike Tyson, Artificial Intelligence, and the World's Best Beers
Tim Ferriss
A psychedelic substance mentioned in the context of Mike Tyson's experience with it and the hypothetical risks for 'sitters'.

Lessons from ~4,500 LSD Sessions and Beyond | Stan Grof | The Tim Ferriss Show (Podcast)
Tim Ferriss
A powerful psychedelic, discussed as present in ayahuasca and certain toad secretions, capable of inducing intense, short-duration spiritual transformations.

Hamilton Morris — Psychedelics, Smart Drugs, and More
Tim Ferriss
A powerful psychedelic that an episode of 'Hamilton's Pharmacopoeia' covers, highlighting the risks of a cocky attitude and instances of accidental death.

The New Frontiers of Mental Health — Brain Stimulation, Rapid-Acting Tools for Depression, and More
Tim Ferriss
A short-acting psychedelic found in plants and the Colorado River toad (Bufo alvarius), discussed for its use on the 'gray day' following ibogaine administration and its potential risks and sustainability concerns.

Dr. Andrew Huberman — The Foundations of Physical and Mental Performance
Tim Ferriss
A potent psychedelic discussed as potentially being commodified as a 'businessman's psychedelic therapy' due to its short duration, raising concerns about the removal of depth from the experience.

Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
All-In Podcast
A powerful psychedelic substance, described as 5 to 10 times more potent than DMT, experienced by Bryan Johnson as a profound reset of consciousness and ego. It is noted for dissolving the default mode network.