Hamilton Morris on Iboga, 5-MeO-DMT, the Power of Ritual, New Frontiers in Psychedelics, and More

Professor of Neuroscience and Psychology at UC Berkeley and author of 'Why We Sleep', serving as Oura's Chief Science Advisor.

A former research biochemist and New York Times best-selling author of 'The Paleo Solution' and 'Wired to Eat,' who created LMNT electrolytes based on a personal need for performance enhancement.

An incredible doctor and popular podcast guest who drinks Dry Farm Wines, even on a ketogenic diet.

A doctor who vetted and introduced Tim Ferriss to the Oura Ring, known for his thorough evaluation of health devices.

A chemist, filmmaker, and science journalist known for his documentary series 'Hamilton's Pharmacopeia,' exploring the chemistry and traditions of psychoactive drugs.

An anthropologist who hypothesized that Cherokee people used toads as psychoactive drugs, a compelling hypothesis later disproven to be related to Bufo Alvarius.

Author of a recent biography about Oliver Sacks, potentially detailing Sacks's drug use.

An astrophysicist who anonymously co-authored a section of Lester Grinspoon's 'Marijuana Reconsidered,' describing his revelatory experiences with cannabis.

A brilliant medicinal chemist responsible for discovering an estimated 200 novel psychedelic compounds, known for his books PiHKAL and TiHKAL, and for openly experimenting with substances he synthesized.

Author of 'Neuropsychedelia' and a new meta-primatology book, whose work is highlighted as interesting and worth reading.

A neurologist and renowned science writer, known for books like 'The Man Who Mistook His Wife for a Hat' and 'Hallucinations,' who implicitly wrote about his own drug experiences.

A renowned mycologist, whose books are recommended for those interested in mushroom cultivation or mushrooms in general.

Author of 'Marijuana Reconsidered,' which included an anonymous contribution from Carl Sagan about his cannabis experiences.

A psychologist and author known for 'The Healing Journey,' which describes profound and lasting changes from psychedelic-assisted therapy.

An exceptional human and experienced facilitator/therapist at Johns Hopkins, with hundreds of legal psilocybin administration sessions.

A New York-based heroin addict in the 1960s who accidentally discovered the anti-addictive effects of ibogaine after using it as a psychedelic and subsequently dedicated his life to advocating for its use.

A controversial LSD chemist known for his dedication to purity and attempting to 'project love into the molecule itself' during synthesis.

An anesthesiologist who experimentally used xenon as an anesthetic, contributing to its limited clinical investigation.

A controversial LSD chemist who took 'neurotic pride' in minimizing environmental damage during his synthesis, aiming to keep all waste in one trash can.

An independent researcher in the 1980s who, inspired by a misconception, was the first human to smoke Bufo Alvarius venom, effectively discovering a new practice.

A well-known figure in the psychedelic community, whose books are recommended for those interested in psilocybin mushrooms.

Author of 'The Wizard of the Four Winds,' a beautiful book on Peruvian cactus shamanism, highly recommended for those interested in mescaline-containing cacti.

A memoir by Oliver Sacks, praised for its beautiful writing and contributions to science writing.

A book by William Richards, described as part clinical primer on best practices with psychedelics and part biographical sections on his fascinating life.

A popular book on sleep, written by Dr. Matthew Walker, who is the Chief Science Advisor for Oura.

A New York Times best-selling book authored by Robb Wolf.

A book by Lester Grinspoon that featured an anonymous contribution from Carl Sagan about his experiences with cannabis.

An encyclopedic compilation by Alexander Shulgin detailing phenethylamines he researched, including synthesis and experiential reports.

A forthcoming three-volume set based on Alexander Shulgin's 1987 class recordings, offering his sharp insights on drugs, drug policy, and research.

A book by Claudio Naranjo that describes immediate revelations and profound, lasting change from psychedelic experiences, contrasting typical gradual psychological change.

A New York Times best-selling book authored by Robb Wolf.

An encyclopedic compilation by Alexander Shulgin detailing tryptamines he researched, including synthesis and experiential reports.

A book by Nicolas Langlitz discussed in the previous podcast episode, covering the history and ideas around psychedelics and the brain.

A book by Oliver Sacks, mentioned in the context of Sacks implicitly describing his own PCP experiences through a medical student character.

A beautiful book by Douglas Sharon that delves into Peruvian cactus shamanism, recommended for those interested in mescaline-containing cacti.

A TV news program from the 1970s that aired a segment on DPT administration to a dying cancer patient, described as a deeply moving piece of television.

A documentary series written and directed by Hamilton Morris, exploring the chemistry and traditions surrounding psychoactive drugs across many countries.

The psychoactive compound found in 'magic mushrooms,' used in hundreds of legal administration sessions by Bill Richards and Mary Cosimano at Johns Hopkins.

A psychoactive plant, mentioned as Hamilton Morris's high school experience with it led him to believe psychedelics were misunderstood.

A psychedelic brew; mentioned as low doses can be more beneficial than high doses, and discussion of its traditional components and evolving usage patterns.

A dissociative anesthetic currently in a 'hype phase' for treatment-resistant depression, but raising concerns about potential urogenital toxicity with widespread use.

A synthetic cannabinoid, which caused a 'fractal of uncertainty' for Hamilton Morris during an unsettling experience in China.

A dissociative anesthetic; mentioned in the context of Oliver Sacks's writings which implicitly referred to his personal experiences with it.

A psychoactive compound, often derived from the Sonoran Desert Toad, which is pharmacologically and تجربely distinct from DMT, inducing near-death like experiences and dissociative effects.

A compound discussed in the context of it being placed in Schedule I in the 1980s despite its therapeutic potential and non-hallucinogenic properties, leading to Shulgin's radicalization.

A psychoactive compound from the iboga plant, discussed as a potent anti-addictive medicine, especially for opioid use disorder, with a unique history of discovery by Howard Lotsoff.

A psychedelic compound, shown being administered to a dying cancer patient in a 60 Minutes segment, highlighting its potential for end-of-life peace.

A low-potency opioid analgesic, largely unregulated in some regions, which has become inexpensive and widespread in West Africa, leading to addiction and a new focus for Iboga's anti-addictive properties.

A synthetic derivative of ibogaine with anti-addictive effects, hypothesized to work through antagonism of the alpha-3 beta-4 nicotinic acetylcholine receptor.

A psychedelic drug, mentioned in the context of clandestine synthesis and chemists' efforts to minimize environmental harm.

A sugar-free electrolyte drink mix, formulated for various dietary needs, including keto, low-carb, or paleo, and for endurance exercise.

A pharmaceutical company developing a xenon inhaler for PTSD, representing a novel approach to psychoactive drug delivery for psychological disorders.

A smart ring that provides personalized sleep and health insights by measuring heart rate, HRV, temperature, activity, and sleep. Endorsed for its accuracy and actionable insights.

A wine company that ships natural wines meeting stringent criteria (low sugar, low alcohol, additive-free, organic), reducing hangovers for Tim Ferriss.

An animal product without pharmacological effect, but whose perceived medicinal value leads to demand and endangerment, used as an example of unsustainable practices.

A frog secretion mentioned as an example of a psychoactive animal product that people should generally avoid using, preferring exhausted all other options.

An animal product without pharmacological effect, sometimes falsely rumored to contain tramadol, leading to severe threats to pangolin populations.

A law passed during the Reagan administration that allows prosecution of compounds arbitrarily defined as analogs of Schedule I controlled substances, significantly impacting psychedelic research.

A book by Oliver Sacks, which is highly regarded for its writing and content.

A chemical extracted from trees used in MDMA synthesis, whose black market sourcing leads to deforestation, but can also be produced synthetically without environmental damage.

Potassium ion channels that regulate heart rhythms; ibogaine binds to these, and high doses can cause fatal arrhythmias, highlighting the need for cautious dosing.

A subclass of chemistry dedicated to finding the most environmentally friendly ways of producing chemicals and reactions.

A euphoric gas known for its use in dentistry, but also an occupational hazard for dental professionals who can develop addiction to it.

An institution recognized for its pioneering research in psychedelic and consciousness studies, particularly regarding Bill Richards and Mary Cosimano's work with psilocybin.

The institution where Hamilton Morris conducts chemistry research.

A rare book by a University of Chicago anthropologist named Fernandez, detailing the Bwiti religion in the 60s or early 70s, highly recommended for understanding Iboga and Bwiti.

An indigenous people, whom anthropologist Jeanette Runquist initially hypothesized used toads for psychoactive purposes, later clarified to be using them for food not psychoactivity.

A neurodegenerative disorder; Hamilton Morris's republishing of a book on Bufo Alvarius raised over $150,000 for research into this disease.

A country in Central West Africa where Iboga rituals are practiced, and where the emergence of opioid addiction has led to modifications in traditional practices.

A country in Central West Africa where Iboga rituals are practiced, and where the emergence of opioid addiction has led to modifications in traditional practices.

A hormone from which 5-MeO-DMT can be synthesized microbially or on an enormous scale with minimal ecological repercussions, offering a sustainable alternative to toad venom.

A noble gas known for being an expensive, euphoric anesthetic with rapid recovery and no known toxicity, explored by Hamilton Morris in the context of Russian clinics.