Aspirin

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

An initial ITP candidate drug that showed a small lifespan extension in male mice at a very low dose, but did not replicate the effect at higher doses.

How A Doctor Cured His Own Terminal Disease | Dr. David Fajgenbaum

Andrew Huberman

Understanding & Conquering Depression

Andrew Huberman

A pain reliever, mentioned as an example that can help certain people with emotional pain.

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)

Stronger By Science

Plausibly could blunt hypertrophy or strength gains, similar to NSAIDs, as it works via similar mechanisms (COX-2 inhibition) and also irreversibly inhibits COX-1, potentially making it worse for hypertrophy than NSAIDs.

#59–Jason Fung, M.D: Fasting as an antidote to obesity, insulin resistance, T2D, & metabolic illness

Peter Attia MD

Cited as an example of a major advance in medicine, accounting for a large percentage of progress.

How to Improve Skin Health & Appearance

Andrew Huberman

A drug used to reduce platelet stickiness to improve heart health, mentioned due to its chemical class being similar to salicylic acid.

How to Improve Brain Health & Offset Neurodegeneration | Dr. Gary Steinberg

Andrew Huberman

An antiplatelet agent that thins the blood, useful for treating people predisposed to clots but increases hemorrhage risk if a vessel bursts.

E51: Supply Chain Shortages, Inflation, DeSantis, Ted Sarandos Netflix Memo, Cancel Culture, Fan Q&A

All-In Podcast

Drug initially recommended as a general heart attack deterrent, but now with revised guidelines due to bleeding risks.

Psychedelics — Microdosing, Mind Enhancing Methods, and More | The Tim Ferriss Show (Podcast)

Tim Ferriss

A common pain reliever with a different safety profile than psychedelics.

Control Pain & Heal Faster with Your Brain

Andrew Huberman

A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation by blocking COX prostaglandin pathways, commonly used for pain but may not be ideal when acute inflammation is beneficial for healing.

367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data

Peter Attia MD

Another prostaglandin inhibitor, shown to have modest protective effects against autism-like symptoms in animal studies and a 13% relative risk reduction in the Swedish cohort study, which argues against acetaminophen's causal link.

Tools for Nutrition & Fitness | Dr. Layne Norton

Andrew Huberman

Mentioned as an example of how a substance can have multiple biochemical pathways, some pro- and some anti-coagulant, but an overall anti-coagulant outcome. It highlights the importance of focusing on outcomes over isolated mechanisms.

Advil, Aspirin, and Tylenol -- What's the difference?

Sabine Hossenfelder

A common pain reliever and NSAID, known for its unique mechanism of permanently disabling COX enzymes and a longer duration of action.

Tools to Reduce & Manage Pain | Dr. Sean Mackey

Andrew Huberman

Functions as an anti-platelet agent at low doses (81mg/day), potentially benefiting heart health, and as an anti-inflammatory at higher doses (325mg or more).

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

An NSAID that is an exception to the FDA's strengthened warning regarding increased risk of heart attack or stroke from short-term NSAID use.