Aspirin

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

An initial ITP candidate drug that showed a small lifespan extension in male mice at a very low dose, but did not replicate the effect at higher doses.

How A Doctor Cured His Own Terminal Disease | Dr. David Fajgenbaum

Andrew Huberman

Understanding & Conquering Depression

Andrew Huberman

A pain reliever, mentioned as an example that can help certain people with emotional pain.

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)

Stronger By Science

Plausibly could blunt hypertrophy or strength gains, similar to NSAIDs, as it works via similar mechanisms (COX-2 inhibition) and also irreversibly inhibits COX-1, potentially making it worse for hypertrophy than NSAIDs.

#59–Jason Fung, M.D: Fasting as an antidote to obesity, insulin resistance, T2D, & metabolic illness

Peter Attia MD

Cited as an example of a major advance in medicine, accounting for a large percentage of progress.

How to Improve Skin Health & Appearance

Andrew Huberman

A drug used to reduce platelet stickiness to improve heart health, mentioned due to its chemical class being similar to salicylic acid.

How to Improve Brain Health & Offset Neurodegeneration | Dr. Gary Steinberg

Andrew Huberman

An antiplatelet agent that thins the blood, useful for treating people predisposed to clots but increases hemorrhage risk if a vessel bursts.

E51: Supply Chain Shortages, Inflation, DeSantis, Ted Sarandos Netflix Memo, Cancel Culture, Fan Q&A

All-In Podcast

Drug initially recommended as a general heart attack deterrent, but now with revised guidelines due to bleeding risks.

Psychedelics — Microdosing, Mind Enhancing Methods, and More | The Tim Ferriss Show (Podcast)

Tim Ferriss

A common pain reliever with a different safety profile than psychedelics.

Control Pain & Heal Faster with Your Brain

Andrew Huberman

A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation by blocking COX prostaglandin pathways, commonly used for pain but may not be ideal when acute inflammation is beneficial for healing.

367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data

Peter Attia MD

Another prostaglandin inhibitor, shown to have modest protective effects against autism-like symptoms in animal studies and a 13% relative risk reduction in the Swedish cohort study, which argues against acetaminophen's causal link.

Tools for Nutrition & Fitness | Dr. Layne Norton

Andrew Huberman

Mentioned as an example of how a substance can have multiple biochemical pathways, some pro- and some anti-coagulant, but an overall anti-coagulant outcome. It highlights the importance of focusing on outcomes over isolated mechanisms.

Advil, Aspirin, and Tylenol -- What's the difference?

Sabine Hossenfelder

A common pain reliever and NSAID, known for its unique mechanism of permanently disabling COX enzymes and a longer duration of action.

Tools to Reduce & Manage Pain | Dr. Sean Mackey

Andrew Huberman

Functions as an anti-platelet agent at low doses (81mg/day), potentially benefiting heart health, and as an anti-inflammatory at higher doses (325mg or more).

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

An NSAID that is an exception to the FDA's strengthened warning regarding increased risk of heart attack or stroke from short-term NSAID use.

Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!

The Diary Of A CEO

Dr. Sinclair takes a baby aspirin daily to inhibit platelets and reduce risks of stroke and heart attack, despite general medical advice changing, due to his high cardiovascular risk.

How to Reclaim Your Brain in 2026 - Dr Andrew Huberman (4K)

Chris Williamson

An existing drug mentioned for its repurposed use in treating colon cancer.

The disaster I never imagined having to worry about

Veritasium

An early drug that highlights the potential for polymorphism, with the speaker mentioning discovering a second form by accident after it had been in use for decades.