GLP-1 agonists

381‒Alzheimer’s disease in women: how hormonal transitions impact the brain, new therapies, & more

Peter Attia MD

Drug class discussed as potential brain health modulators; evidence discussed is preliminary.

197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D

Peter Attia MD

A class of drugs mentioned as having life-prolonging effects and being a key intervention for obesity.

How Sugar & Processed Foods Impact Your Health | Dr. Robert Lustig

Andrew Huberman

A class of drugs like semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) that reduce gastric emptying and affect satiety, used for weight loss and diabetes.

#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications

Peter Attia MD

A class of drugs that are gaining popularity for their effect on energy intake, leading to weight loss and some reversal of fatty liver disease.

How to Quiet the Ruminative Mind and Avoid The Traps of Self-Help — Tim Ferriss

Tim Ferriss

A class of drugs with observed amazing results in literature, but with unknown long-term effects.

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

Peter Attia MD

A class of drugs that work by supplying a hormone that tells the pancreas to release insulin after eating and shuts down glucagon production, leading to weight loss and improved cardiovascular prognosis.

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects

Andrew Huberman

A class of drugs that increase insulin sensitivity and initially cause the body to make more insulin, used to treat type 2 diabetes.

167 - Gary Taubes: Bad science and challenging the conventional wisdom of obesity

Peter Attia MD

A class of drugs mentioned as a 'fascinating' new development in obesity and diabetes treatment, possibly changing the public health landscape.

How To Build A Truly Abundant Future

Y Combinator

DOGE unveils a roadmap, Unlocking GDP Growth, WW3 escalation, Fat cell memory

All-In Podcast

Drugs like Ozempic and Wegovy, which are effective for weight loss but often lead to weight regain when discontinued, are discussed in the context of epigenetic memory in fat cells.

252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting

Peter Attia MD

A class of drugs (e.g., semaglutide, tirzepatide) effective for weight loss by squashing appetite. Discussed with reservations about liberal use, stressing the importance of high protein intake to prevent muscle loss.

Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent [AMA 45 sneak peek]

Peter Attia MD

A class of drugs that are the primary topic of discussion, known for their effects on blood glucose and weight loss.

378 ‒ Women’s health & performance: how training, nutrition, & hormones interact across life stages

Peter Attia MD

Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Andrew Huberman

A class of glucagon-like peptide analogs, including popular drugs like Ozempic and Mounjaro, primarily used for glucose control in type 2 diabetics, with weight loss as a significant side effect.

Tools for Nutrition & Fitness | Dr. Layne Norton

Andrew Huberman

A class of drugs that mimic glucagon-like peptide-1, a gut hormone that reduces appetite and slows gastrointestinal motility. These drugs have a longer half-life than natural GLP-1, making them effective for weight loss. Viewed as a net positive for public health despite potential side effects and concerns about lean mass loss.