Cynthia Kenyon
A scientist whose lab work with worms revealed that restricting glucose or underexpressing insulin-related genes could increase lifespan, influencing modern longevity research.
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Videos Mentioning Cynthia Kenyon
#41–Jake Kushner, M.D.: How to thrive with T1D and the valuable insights that can benefit anyone
Peter Attia MD
A scientist whose work in C. elegans demonstrated that modest alterations in insulin signaling could double lifespan, inspiring insights into hyperinsulinemia and aging.
175 - The biology of aging, rapamycin, and other interventions that target the aging process
Peter Attia MD
A researcher cited for her perspective on disease-based definitions of aging, arguing that if 'everyone has cancer by a certain age, then it's normative aging, not a disease.'
#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19
Peter Attia MD
A researcher whose papers on genetic mutations doubling lifespan in worms inspired Joan Mannick to pursue aging research.
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
Peter Attia MD
Scientist whose paper on C. elegans showed that knocking down a single gene could double the animal's lifespan, opening up the field of aging research.
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP
Peter Attia MD
A researcher whose early work in C. elegans demonstrated that single gene mutations (Daf-2 and Daf-16) could dramatically extend lifespan, challenging prevailing scientific beliefs.
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
Peter Attia MD
The discovery of the daf-2 mutation in C. elegans, a nematode worm, by Cynthia Kenyon, coincided with initial work on sirtuins and longevity genes.
#66 – Vamsi Mootha, MD: Aging, T2D, cancer, dementia, Parkinson’s—do all roads lead to mitochondria?
Peter Attia MD
At UCSF and Calico, she conducted early RNAi screens in worms to identify genes associated with longevity phenotypes.
252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting
Peter Attia MD
A scientist credited with making the discovery of lifespan extension in C. elegans through genetic manipulation (daf-16/daf-2 mutation).
Micronutrients for Health & Longevity | Dr. Rhonda Patrick
Andrew Huberman
Scientist who discovered in the '90s that decreasing insulin signaling pathway and IGF-1 in C. elegans worms could increase their lifespan by 100% by activating FOXO3.
#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+
Peter Attia MD
A researcher known for her work on the daf-16 mutants in C. elegans, which demonstrated significant lifespan extension by attenuating IGF-1 signaling.
The Insulin & Glucose Doctor: This Will Strip Your Fat Faster Than Anything!
The Diary Of A CEO
A scientist whose lab work with worms revealed that restricting glucose or underexpressing insulin-related genes could increase lifespan, influencing modern longevity research.
The longevity benefits of proper protein intake and strength training | Rhonda Patrick & Peter Attia
Peter Attia MD
A scientist credited with discovering the role of the daf-2 gene (an IGF-1 receptor analog) in extending lifespan in C. elegans.