Key Moments

TL;DR

Virtual humans are now nearly indistinguishable from real ones — but each one costs $1M to capture.

Key Insights

1

Delaying caffeine for 60-90 minutes after waking allows for continued adenosine clearance, potentially reducing the common afternoon energy crash experienced by many, by about 50%. This also amplifies the natural morning cortisol peak, which can boost immune function, energy, alertness, and mood by nearly 50% through bright light exposure.

2

Non-sleep deep rest (NSDR) or Yoga Nidra, a 10-30 minute practice, can replenish dopamine stores in the basal ganglia and may help clear residual adenosine, with ongoing collaborations with Dr. Matt Walker to evaluate its sleep-mimicking effects.

3

Becoming a morning person or shifting sleep patterns requires consistently stacking four 'zeitgebers' (timekeepers): morning bright light (e.g., 10,000 Lux indoors or outdoor sunlight in the first hour of waking), exercise/movement, caffeine (though best delayed for 60-90 mins for afternoon crash mitigation), and social interaction, with consistency for about three days for a phase shift.

4

People's beliefs are more durably impacted by stories than statistics; the average impact of statistics on beliefs fades by 73% over a day, while the impact of a story fades by only 32%, suggesting the brain organizes information in beginning, middle, and end narratives.

5

Avoiding catastrophes or 'multiplying by zero' (e.g., reckless behavior after consistent healthy habits) is more profitable than simply expediting success, highlighting the importance of eliminating detrimental factors.

6

The 'lonely chapter' is a necessary period of personal growth where individuals outgrow old relationships and routines before establishing new ones, often feeling isolated due to the discordance between who they were and who they are becoming.

Strategic caffeine and light exposure can eliminate the afternoon crash

Many people habitually reach for coffee immediately upon waking, but this habit might contribute to the common afternoon energy crash. Adenosine, a molecule that accumulates the longer you're awake, is responsible for feelings of sleepiness and fatigue. Caffeine works by blocking adenosine receptors. However, if consumed too early after waking, residual adenosine that hasn't been cleared during sleep can persist, and new adenosine continues to accumulate. Once the caffeine wears off (typically 3-4 hours later), this accumulated adenosine can lead to a significant dip in energy, often between 1 PM and 4 PM. To counteract this, delaying caffeine intake for 60-90 minutes after waking can be highly effective. This delay allows the body to naturally clear more residual adenosine, preventing it from being 'trapped' by caffeine. Furthermore, exposure to bright light—ideally sunlight, or 10,000 Lux indoor light if sunlight is unavailable—within the first hour of waking can significantly amplify the natural morning cortisol peak by nearly 50%. This cortisol surge is a powerful pro-wakefulness mechanism that bolsters the immune system, enhances energy and alertness, and improves mood, while simultaneously suppressing anti-wakefulness systems like melatonin and adenosine. This two-pronged approach—delayed caffeine and early bright light—can help synchronize the body's natural rhythms, leading to more sustained energy throughout the day and reducing reliance on caffeine to combat grogginess.

Non-sleep deep rest (NSDR) offers a powerful mental reset

Beyond traditional sleep, practices like non-sleep deep rest (NSDR), also known by its ancient name Yoga Nidra, can provide a profound sense of rejuvenation. Engaging in 10-30 minutes of NSDR upon waking, or during an afternoon slump, can help clear residual adenosine and replenish dopamine stores in the basal ganglia—a brain area crucial for mental and physical action. This practice involves keeping the body still while maintaining an active mind, a state that remarkably mimics rapid eye movement (REM) sleep. While ongoing research, including collaborations with Dr. Matt Walker, is exploring the exact mechanisms and extent to which NSDR can substitute for traditional sleep, anecdotal evidence from countless individuals suggests it's a zero-cost, highly effective tool for energetic replenishment, mental clarity, and stress reduction.

Aligning your circadian rhythm: The four zeitgebers

For those seeking to become 'morning people' or simply optimize their daily energy, aligning the circadian rhythm is paramount. This internal 24-hour clock, primarily governed by the suprachiasmatic nucleus (SCN) in the brain, can be entrained by four main 'zeitgebers' (German for 'time-givers'). The most potent is bright light exposure in the morning. Looking towards the sun upon waking (without sunglasses) or using powerful artificial lights (10,000 lux) signals to the SCN that it's daytime, initiating a cascade of alertness-promoting hormones. The second zeitgeber is physical activity or movement, which creates a direct neuronal connection from the brainstem to the SCN, further solidifying the wake-up signal. Caffeine, the third, can also help entrain the clock, though delaying it remains beneficial for afternoon energy. Finally, consuming food and engaging in social interactions early in the day also serve as powerful timekeepers. Consistently stacking these four elements for approximately three days can successfully 'phase advance' the circadian clock, making it easier to wake up earlier and feel more alert without an alarm.

Understanding the 'lonely chapter' in personal growth

Personal transformation often involves a challenging phase referred to as the 'lonely chapter.' This period describes the experience of outgrowing existing social circles and routines while not yet having established new ones that align with one's evolving self. It's a time of inherent isolation, fraught with the temptation to regress to old habits and the uncertainty of whether the personal growth journey will lead to desired outcomes. The 'lonely chapter' is not a 'bug' but a 'feature' of genuine self-development—a necessary cost for individuals committed to becoming a different version of themselves. During this time, activities that may seem unproductive, like watching educational videos instead of partying, can create a 'discordance' that prompts deeper reflection and ultimately reshapes one's life. The successful navigation of this chapter often hinges on leveraging internal motivation, embracing solitude, and eventually finding new communities that resonate with the transformed individual. This process highlights an uncomfortable truth: significant change frequently demands letting go of what's comfortable and familiar, even if it means temporary periods of isolation.

The power of intuition and somatic signals in decision-making

While rational thought is crucial, accessing and leveraging intuition, or the body's 'felt sense,' can be a powerful tool for navigating life and making decisions. The nervous system, encompassing both brain and body, communicates through both precise cognitive processes and more 'crude' yet highly sensitive somatic signals. Exercises like those developed by Martha Beck, involving imagining intensely positive or negative scenarios and observing the body's subtle, pre-linguistic responses (contraction for aversion, expansion for draw-in), can train individuals to attune to these intuitive 'yes' or 'no' signals. This taps into the unconscious mind's wisdom, which has accumulated experience over a lifetime. Just as the retina has a highly sensitive but low-acuity rod system and a less sensitive but high-acuity cone system for vision, the body's intuitive signals are broadly sensitive to environmental cues, while conscious thought provides nuanced analysis. Integrating these two systems—combining detailed knowledge with a deeper, more sensitive bodily intuition—is crucial for developing 'virtuosic' decision-making, where one can both grasp the fine details and the macroscopic context of any situation.

Navigating public scrutiny and personal crisis

Experiences of intense public scrutiny, as faced by Dr. Huberman, underscore several critical lessons about media, community, and personal resilience. One stark realization was the prevalence of misinformation and deliberate narrative spinning within some media outlets, often leveraging an individual's public profile for 'clicks' rather than seeking truth. This experience highlighted the stark contrast with the authenticity often found in podcasting, where creators generally communicate their genuine selves, fostering deeper trust with their audience. Personally, navigating such a crisis involved assembling a trusted 'committee' of friends, family, and colleagues whose objective perspectives helped filter misinformation and provide grounding support. It also reinforced the importance of focusing on generative work—continuing to teach and share science—to maintain purpose. Remarkably, such challenging times can paradoxically lead to unexpected growth, both personal and professional, as communities rally and show profound support. Prayer, for Dr. Huberman, emerged as an anchoring practice during this period, offering clarity and a sense of direction when external circumstances felt overwhelming, demonstrating how diverse tools—physiological regulation, social support, and spiritual practices—converge to navigate emotional intensity effectively.

The lasting impact of stories over statistics

Research shows a significant 'story-statistic gap' in memory and belief formation: the impact of statistics on beliefs fades by 73% over a day, while stories degrade by only 32%. This implies that narratives, with their inherent beginning, middle, and end structures, are far more memorable and influential than raw data. The human brain is wired to organize information sequentially and emotionally, a trait evident even in learning the alphabet through song. This reality has profound implications, particularly in areas like politics, where crafting compelling narratives is often more effective in swaying public opinion than presenting statistical facts. While scientific communication often prioritizes data, understanding the brain's preference for story underscores the importance of embedding facts within relatable human experiences for lasting impact. Even 'flashbulb memories'—vivid, emotionally charged recollections of significant events (like collective responses to a public crisis)—illustrate how adrenaline released during impactful moments helps consolidate memories with rich contextual details, further cementing the power of experience and narrative.

Prioritizing the basics for long-term health and vitality

While cutting-edge longevity interventions and supplements abound, the bedrock of long-term health and vitality lies in foundational practices. Dr. Huberman emphasizes a return to 'the basics': consistent sleep (6-8 hours), regular resistance training (3 times/week), varied cardio (long, medium, sprint runs), appropriate hot and cold exposure (saunas, cold plunges), a diet of mostly unprocessed foods, limited alcohol intake, and addressing addictions. These habits are not just for performance but serve as a robust physical and mental 'preparation' for life's inevitable challenges, allowing for resilience during stressful periods. While specific supplements like sublingual NMN (for hair/nail growth and morning energy, not necessarily longevity) or bpc 157 (for injury recovery, used cautiously due to angiogenesis risks and lack of human data) might be explored, they should complement, not replace, these core lifestyle tenets. Moreover, the 'fire hose' of health information available today necessitates critical filtering: focusing on timeless, evidence-based practices and being wary of overly dogmatic or dangerously unproven claims. Ultimately, a 'joyful life' and maintaining vigor—as exemplified by elders who consistently integrate these practices—are crucial, rather than solely pursuing extreme longevity at the expense of quality of life.

Optimizing Energy & Focus: Daily Protocols

Practical takeaways from this episode

Do This

Delay morning caffeine for 60-90 minutes after waking to allow adenosine clearance.
Perform 10-30 minutes of Non-Sleep Deep Rest (NSDR) or Yoga Nidra upon waking.
View bright light (sunlight outdoors or 10,000 Lux indoor light) first thing in the morning to amplify cortisol and suppress melatonin.
Combine morning light viewing with exercise or movement (e.g., walking, jumping jacks) to entrain circadian clock.
View afternoon sunlight (even 5 minutes) to reduce the melatonin-suppressive effects of evening bright light.
Pay attention to your natural cognitive and physical rhythms to schedule focused work (e.g., early morning and early afternoon).
Build a strong support network in good times, as these relationships will be crucial during challenging periods.
Prioritize 6-8 hours of quality sleep nightly, viewing it as essential for recovery and performance. Win by sleeping.
Engage in consistent physical training (3x/week resistance, 3x/week cardio, hot/cold exposure) as preparation for life's challenges.
Cultivate joy in your daily activities, as 'joy is efficiency', making effort feel less expended and leading to greater output.
When facing emotionally intense periods, gather a trusted committee of advisors to gain objective perspectives.
Engage in prayer as a grounding practice for clarity and surrender of control over uncontrollable circumstances.
Focus on real-world actions and creations (writing, music, craft) rather than passive consumption of social media.
Be a 'selective filter' for advice, especially during crises, and learn to discern genuine input.
Embrace 'selective repulsion' in life, actively avoiding things that are not beneficial for your growth and well-being.
Seek formal, rigorous training in your chosen craft and commit to relentless practice and iteration to build deep expertise.

Avoid This

Consume caffeine immediately upon waking if you experience an afternoon energy crash.
View bright artificial light after 9:30 PM (or use red-lens glasses if unavoidable).
Overindulge in caffeine in the afternoon, as it can disrupt evening sleep.
Neglect sleep, as it is critical for physical and mental restoration and brain function.
Try to force a specific daily schedule if it doesn't align with your natural rhythms.
Become isolated during difficult times; leverage your support network or seek guidance from books and podcasts.
Expect instant glory or success from personal growth; endure the 'lonely chapter' as a necessary phase.
Over-rely on pharmacology for sleep if non-pharmacological methods are available and effective for you.
Blindly follow advice without critical evaluation, as some suggestions may be ill-suited or uninformed.
Allow overthinking to create more problems than it solves, unless it's for a truly complex problem.
Uncritically believe all media narratives; recognize that stories can be biased or fabricated and seek context.
Take experimental supplements or drugs like BPC-157 or testosterone without proper medical consultation and understanding of risks (e.g., angiogenesis, persistent hopelessness).
Multiply by zero: undermine all your positive efforts by making a single catastrophic error (e.g., driving without a seatbelt, meditating while running in traffic).

Common Questions

Adenosine is a molecule that accumulates in your brain and body the longer you are awake, leading to feelings of sleepiness and fatigue. It is cleared from your system during sleep. If you don't get enough sleep, residual adenosine can remain, contributing to morning grogginess and afternoon energy crashes.

Topics

Mentioned in this video

People
Alex Hormozi

Mentioned as having two deviated septums and needing nasal devices to breathe. He also introduced the concept of the 'lonely chapter' in personal growth.

David Sinclair

A researcher who popularized NMN, leading to the FDA classifying it as a drug under evaluation in clinical trials, affecting its supplement status.

Kelly Boys

A woman with a lovely voice who provides NSDR scripts online, often used by the speaker.

Joe Rogan

A podcaster and friend who playfully teases the speaker about his cold plunge temperature. Also mentioned in relation to his experience with NAD+ infusions and the CNN narrative.

Shane Gillis

A comedian who humorously refers to watching World War II documentaries as 'early onset Republican'.

Dana White

President of the UFC, mentioned in the humorous context of Joe Rogan's influence and connection to the UFC.

Lex Fridman

A podcaster and friend of Andrew Huberman, who is Russian and joked about not needing a cold plunge. He also showed up to support Huberman during a difficult time.

Jason Diamond

A world-renowned facial plastic surgeon and friend, who skillfully mended Andrew Huberman's injury without a scar, emphasizing the importance of quick medical attention.

Ross Edgley

An extreme endurance athlete who swam around the UK and completed the world's longest single-distance non-stop swim (300 miles), embodying extraordinary human spirit.

Rory Sutherland

Vice chairman of Ogilvy advertising, known for his insights on reframing experiences, quoted for his humorous example of smoking to appear as a philosopher while staring out a window.

Tim Armstrong

A good friend of Andrew Huberman who provided support during a difficult time, and is known for writing a song every day.

Taylor Swift

A popular musician, used as an example to illustrate that popularity in one genre doesn't diminish the value of other music genres, analogous to different scientific or health perspectives.

Paul Conti

A psychiatrist and podcast guest who discussed the 'league of reasonable people' and insights into how trauma can repattern old memories.

Jim Thiebaud

From Deluxe Distribution (World Skateboarding), a long-time mentor and friend who offered support during difficult times, going back to Andrew Huberman's teenage years.

Erik Erikson

A great psychologist who discussed developmental arcs at every stage of life, from birth until death.

Robert F. Kennedy Jr.

A political candidate mentioned in relation to a false narrative regarding Joe Rogan's endorsement.

Robert Sapolsky

A Stanford professor and mentor who has been generous with advice on navigating public-facing roles and transitions from laboratory work, and whose lectures are very popular.

Tim Ferriss

Podcaster and friend whom Andrew Huberman listened to as a junior professor, finding solace and community in his content during a period of isolation.

Joe Hudson

From Art of Accomplishment, who defines joy as efficiency and suggests asking, 'What would this be like if it was 10% more enjoyable?'

Brian Callen

A comedian and actor who was challenged by Tim Kennedy to an extreme cold plunge, showcasing his acting skills to avoid it.

Rob Moore

Andrew Huberman's podcast producer, part of the trusted committee of people he relied on during a period of public scrutiny.

Martha Beck

A Harvard triple-degreed individual who developed self-help tools, providing useful exercises for developing intuition and mapping out a 'perfect day'.

Cam Hanes

Known for pushing himself very hard physically, understood by Andrew Huberman as being 'pulled' by an intrinsic drive rather than 'pushing' himself, and seen as a protector against muscle wasting.

David Goggins

An athlete and motivational speaker quoted for his idea that it's easier than ever to become extraordinary by focusing on real-world actions over digital consumption.

Jocko Willink

Known for his high energy levels and early waking. The speaker questions if he has a rare genetic mutation for faster adenosine clearance and recounts a challenging sauna 'factory reset' protocol with him.

Kamala Harris

U.S. Vice President, mentioned in a video mocking her that Donald Trump tweeted.

Matt Walker

Author of 'Why We Sleep' and a collaborator with Andrew Huberman on a project evaluating how Non-Sleep Deep Rest (NSDR) impacts brain states, particularly in relation to mimicking sleep.

Anthony Bourdain

A chef and TV personality who passed away by suicide. A documentary about him, 'Roadrunner', is discussed, highlighting his sensation-seeking nature and connection to the New York punk rock scene.

Joe Strummer

Another artist mentioned in the context of the punk rock scene.

Steve Ruggieri

Former team manager at Thunder and Spitfire skateboard companies, who confirmed Andrew Huberman's past in skateboarding, correcting false narratives from the media and providing unexpected emotional support.

Elon Musk

CEO of X (formerly Twitter) and other companies, who engaged in a live session with Donald Trump, reflecting new media dynamics.

Bryan Johnson

A longevity enthusiast known for his extreme biohacking protocols. Andrew Huberman views him as a 'scout in an army,' exploring the frontiers of longevity and providing insights.

Oliver Sacks

A renowned neurologist and author. A documentary about him is mentioned, and his life experience serves as a mentor/guide for the speaker through hard times.

Cole Hocker

An Olympic runner mentioned for his ability to win gold from a fifth position, symbolizing peak athletic performance.

Rick Rubin

Known for always asking 'How are you feeling?' and for his diligence in using red lens glasses at night to block blue light. He also taught the speaker a trick for remembering dreams.

Tim Kennedy

An individual with high visual acuity, known for tough challenges like the 'Tim Kennedy alarm' protocol, and a friend of Brian Callen.

Glenn Jeffrey

A colleague at University College London whose lab published beautiful studies showing that red light therapy can offset age-related vision decline.

Joanna Steinglass

A researcher at Columbia University School of Medicine whose laboratory received funding for her goal of finding a cure for anorexia nervosa, the deadliest psychiatric illness.

Whitney Cummings

A podcaster and friend who is part of Andrew Huberman's support network and recognized for her dedication to her craft.

James McGaugh

A leading researcher in memory, whose review on flashbulb memories references historical methods of inducing strong memory formation.

Richard Ramirez

A serial killer, the subject of a terrifying documentary set in Los Angeles.

Jay Shetty

Mentioned as someone who works extremely hard to improve his craft, serving as an example of dedication and discipline.

Donald Trump

Former U.S. President, whose account was reactivated on Twitter/X, and who announced a live session with Elon Musk, also posted on Truth Social.

David Senra

A podcaster whose show is highly recommended for its biographies and autobiographies, and who is considered an amazing podcaster and a next-level talent.

Lane Norton

A respected individual with whom Andrew Huberman has different scientific thresholds, particularly regarding the reliance on randomized controlled trials versus anecdotal evidence.

Jimmy Fallon

Host of The Tonight Show, mentioned as a platform Andrew Huberman appeared on after a period of intense public scrutiny, indicating growth in his public profile.

Peter Attia

Mentioned as being bullish on Rapamycin and as a source for understanding current longevity research and the lack of clinical data on compounds like BPC-157.

Ryan Suave

A talented trauma therapist in Florida who spoke about Buddhist traditions of 'burning down the scums' (misperceptions) to eliminate suffering.

Eddie Chang

Chair of neurosurgery at UCSF, described as one of the best neurosurgeons in the world, with whom Andrew Huberman collaborated on recording from the human brain.

Supplements
TB-500

A peptide mentioned in the context of Achilles rupture recovery, noted for being very restricted in its use, contrasting with BPC-157.

Cannabis

Mentioned as an example of a drug with a nuanced view nowadays, being potentially beneficial for some and terrible for others, contrasting with an 'all drugs bad' perspective.

NR

A precursor to NMN, some proponents believe it's preferable to NMN due to anti-inflammation effects and more ready conversion to NAD+. Andrew Huberman did not notice tangible effects from it.

Cerebrolysin

A drug sold in Europe but not the US, that accelerates nerve growth and is of interest to Bryan Johnson and others for its potential cognitive benefits. Chris Williamson is currently taking it.

NAD

A molecule for which NMN and NR are precursors. Direct infusions of NAD+ are discussed as a potentially effective but painful method of delivery, especially when fast-infused.

Phosphatidylcholine

A supplement taken for Chris Williamson's aggressive mold detox protocol.

NMN

A precursor to NAD+ popularized by David Sinclair. Andrew Huberman takes it sublingually not for longevity, but for faster hair and nail growth and increased morning energy, despite its complex regulatory status with the FDA.

BPC-157

An experimental peptide with zero human data but extensive animal data for injury repair. Andrew Huberman uses it for faster healing but cautions against continuous use, oral versions, and the risk of angiogenesis in tumors.

glutathione

A supplement taken via IV, part of Chris Williamson's aggressive mold detox protocol.

Creatine monohydrate

A supplement taken by Andrew Huberman since age 17, known for muscle growth and cognition, and proven not to harm kidneys. It's a stable formulation that doesn't need constant iteration.

Melatonin

A hormone released from the pineal gland that contributes to sleepiness. Bright light exposure, especially in the morning, can suppress melatonin levels.

Caffeine

A commonly used drug (consumed by over 90% of adults) that blocks adenosine receptors, preventing sleepiness. Its effects wearing off lead to the 'caffeine crash' as accumulated adenosine binds to receptors.

Berberine

Referred to as 'poor man's Metformin,' it can cause hypoglycemia if not taken with carbohydrates, and Andrew Huberman experienced negative side effects unless he had 'cheat days' for its use.

Pinealon

A peptide mentioned for its connection to pineal gland regeneration and support for sleep, with future data expected.

Organizations
NIH

The National Institutes of Health, mentioned as a government body involved in funding scientific research, alongside the FDA.

UCSF

The University of California, San Francisco, where Dr. Eddie Chang is the chair of neurosurgery, collaborating on research that involves recording from the human insula.

Stanford University

Andrew Huberman's academic institution, where he teaches and conducts research, and which has been supportive of his podcast and philanthropic efforts.

FBI sniper teams

Mentioned as relying on LMNT for its electrolyte benefits, alongside Olympic athletes and prominent podcasters.

Brain Initiative

A major initiative launched during the Obama administration to fund brain research, which later experienced a significant budget cut, impacting neuroscience laboratories.

FDA

The Food and Drug Administration, whose approval is critical for drugs like MDMA and which has regulations regarding supplements like NMN being sold as drugs.

Columbia University School of Medicine

The institution where Joanna Steinglass leads a laboratory focused on curing anorexia nervosa, receiving philanthropic funding.

Art of Accomplishment

A group or set of teachings associated with Joe Hudson's unique definition of efficiency and practice of cultivating joy.

Lander Boton School of Life

A source of philosophy videos that Chris Williamson watched while transitioning from his old life as a club promoter, providing solace during his 'lonely chapter'.

University College London

The institution where Glenn Jeffrey, a colleague of Andrew Huberman, conducts research on red light therapy and vision.

Obama Administration

The US presidential administration during which the Brain Initiative was launched, infusing over a hundred million dollars into brain research.

Trump administration

The US presidential administration that maintained funding for the Brain Initiative in the period following the Obama administration, though under a different name.

Drugs & Medications
Companies
YouTube

A video platform mentioned for its continuous updates and algorithms, reflecting the scientific process of iteration and improvement.

LMNT

An electrolyte drink mix containing sodium, potassium, and magnesium, recommended for hydration, reducing muscle cramps and fatigue, optimizing brain health, regulating appetite, and curbing cravings. Andrew Huberman and Chris Williamson both enjoy and use it, and it's relied upon by Olympic athletes and FBI sniper teams.

Apple

A technology company cited as an example of continuous product improvement and innovation based on mimicking the scientific process.

Truth Social

A social media platform where Donald Trump posted, challenging a narrative about Joe Rogan's political endorsements.

Meta Platforms

The parent company of Instagram (and Facebook), mentioned as a continuously evolving entity that mimics the scientific process.

Eight Sleep

A sleep tracker and cooling bed technology with a new feature that lifts the head to help with snoring. It provides laboratory-grade sleep tracking and is constantly being improved.

Marrick Health

A health service described as offering sophisticated and comprehensive lab work for over 100 biomarkers, providing insights into hormone profile, cardiovascular health, and organ function.

Momentous

A company that makes high-quality supplements, known for rigorous third-party testing, with Andrew Huberman as their scientific advisor.

Ogilvy

An advertising agency where Rory Sutherland is the Vice Chairman, known for his insights on reframing and perception.

Instagram

A social media platform, mentioned for its constant updates and algorithms, reflecting the scientific process of iteration and improvement.

Netflix

A streaming service, mentioning that afternoon sunlight exposure can act as a 'Netflix inoculation' to partially offset the negative effects of bright light from screens at night on melatonin suppression.

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