mTOR

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

Andrew Huberman

Mammalian Target of Rapamycin, a pathway abundant in developing and growing cells, targeted by drugs like Metformin and Rapamycin for potential lifespan extension influences.

171- Longevity science: caloric restriction studies, aging biomarkers & possible longevity molecules

Peter Attia MD

A gene that when suppressed can have multiple health benefits, which can also be achieved through fasting periods.

#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19

Peter Attia MD

Target of Rapamycin, a protein kinase that regulates cell growth, proliferation, protein synthesis, and metabolism. Its inhibition is central to the action of Rapamycin and Metformin.

#163 - Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training

Peter Attia MD

Mammalian Target of Rapamycin, a protein kinase that regulates cell growth, proliferation, and survival, and is stimulated by leucine and certain mechanical signals in muscle tissue.

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Peter Attia MD

Mechanistic Target of Rapamycin, a master integrator of nutrient and growth factor availability that regulates cell growth, protein synthesis, lipid synthesis, and resource conservation.

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

Peter Attia MD

A complex that acts as a master decision-maker in cells, influencing whether they divide or enter a state of resource conservation, inhibited by Rapamycin and caloric restriction.

The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

Tim Ferriss

The protein that Rapamycin inhibits; it promotes growth and is targeted by some bodybuilders. Its inhibition can paradoxically maintain muscle function better with age.

Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More

Tim Ferriss

A protein complex that Rapamycin inhibits, central to cellular growth and metabolism. Giving mTOR a rest is a purpose of fasting.

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

Mammalian target of Rapamycin, a protein kinase that regulates cell growth, proliferation, and survival, and is inhibited by Rapamycin.

#35 – Nir Barzilai, M.D.: How to tame aging

Peter Attia MD

A protein kinase whose activity is decreased by Metformin, leading to increased autophagy, a key pathway in aging.

#10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — living longer, healthier & turning back the clock

Peter Attia MD

A protein kinase that regulates cell growth, proliferation, and survival, central to aging research and rapamycin's mechanism.

David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189

Lex Fridman

A cellular mechanism that responds to certain amino acids (abundant in meat) and can shorten lifespan when activated; restricting these amino acids or taking drugs like Rapamycin can extend lifespan.

Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance

Andrew Huberman

A cell signaling pathway that leads to muscle growth.

Supercharge Exercise Performance & Recovery with Cooling

Andrew Huberman

Mammalian target of Rapamycin, a pathway involved in muscle adaptation for growth and strength, which can be inhibited by excessive cold exposure post-exercise.

[AUDIO FIXED] Glycogen Loading, Lower Back Pain, PowerBuilding, & Physical Culture with Ben Pollack

Stronger By Science

A key signaling cascade implicated in muscle hypertrophy, which showed a larger increase in gene expression in the identical twin receiving phototherapy.

Glycogen Loading, Lower Back Pain, PowerBuilding, and Physical Culture with Ben Pollack (Episode 28)

Stronger By Science

A protein implicated in the main hypertrophy signaling cascade, whose gene expression showed a larger increase in the twin receiving phototherapy.

The Longevity Expert: Is There A Link Between Milk & Cancer? + Ozempic Can Really Mess You Up!

The Diary Of A CEO

Mammalian target of rapamycin, a pathway involved in cellular buildup and muscle synthesis. Activating it is good for muscle growth, but inhibiting it (e.g., through starvation or Rapamycin) activates cellular cleanup and repair.

Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

FoundMyFitness

Tools for Nutrition & Fitness | Dr. Layne Norton

Andrew Huberman

A signaling pathway crucial for cellular growth and protein synthesis. Its activation by leucine leads to downstream effects on protein translation.

Supplements for Longevity & Their Efficacy | Dr. Peter Attia

Andrew Huberman

A molecule robustly expressed during development and associated with cellular growth; its activity is often targeted by longevity approaches like caloric restriction and rapamycin.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

A pathway in skeletal muscle responsible for new protein synthesis, activated by IGF-1.

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

Andrew Huberman

A protein kinase that responds to insulin; its activation can be reduced by drugs like Rapamycin, mimicking a fasting state.

Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)

Tim Ferriss

A protein complex involved in cell growth and proliferation; chronic activation is seen as detrimental, but intermittent activation is crucial for immunity and stress response.

Dr. Dominic D'Agostino on Fasting, Ketosis, and The End of Cancer

Tim Ferriss

A signaling pathway associated with driving cancer growth and proliferation, which leucine can activate.