Resveratrol
polyphenol with a stilbene skeleton
Common Themes
Videos Mentioning Resveratrol
How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging
FoundMyFitness
A polyphenol that, when combined with NR in a clinical trial for peripheral artery disease, not only offered no benefit but blocked some of NR's positive effects.
AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
Andrew Huberman
Discussed as a potential longevity supplement, but current evidence suggests it does not extend lifespan, though it may have other health benefits.
Russell Kane: How To Build Confidence & Stay Young | E79
The Diary Of A CEO
A polyphenol Russell Kane takes in its trans-resveratrol form (1 gram daily) alongside NMN for its anti-aging properties.
The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show
Tim Ferriss
A polyphenol from red wine, initially popularized as a sirtuin activator and purported longevity compound. Later research, including a meta-analysis, showed no consistent lifespan extension effect and it's considered a 'dirty drug'.
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP
Peter Attia MD
A compound popularized for alleged anti-aging benefits, especially in relation to red wine. ITP studies (at high doses on normal diets) found no significant lifespan extension, debunking earlier findings in mice poisoned with high-fat diets.
The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman
A red wine molecule and sirtuin activator, shown to extend lifespan in mice when given every other day, and needs to be taken with a fatty substance for absorption.
#35 – Nir Barzilai, M.D.: How to tame aging
Peter Attia MD
A natural polyphenol and sirtuin activator discussed for its anti-aging potential, but with questions regarding its bioavailability and effective dosing in humans.
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
Peter Attia MD
A molecule that stimulates sirtuins, found in grapes and wine, which gained fame for promoting longevity phenotypes in animal models, though the 'French paradox' connection is a 'spoiler alert, not true'.
#18 – Richard Isaacson, M.D.: Alzheimer’s prevention
Peter Attia MD
An intervention that Richard Isaacson mentioned was referenced in a paper about Alzheimer's but did not hold up with specific evidence in that context according to Attia's team's review.
#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD
Peter Attia MD
A plant molecule found in red wine, taken in high doses by David Sinclair, shown to activate sirtuin enzymes and extend the lifespan of mice on a Western diet.
David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189
Lex Fridman
A xeno-hormetic molecule produced by plants (e.g., grapevines) under stress, which activates the SIRT1 enzyme in humans, extending lifespan and slowing brain aging.
201 - Deep dive back into Zone 2 Training | Iñigo San-Millán, Ph.D. & Peter Attia, M.D.
Peter Attia MD
Mentioned as a historical example of a longevity supplement that showed significant promise in mouse studies but failed to demonstrate similar effects in humans, highlighting the caution needed when extrapolating animal research to human health.
Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
FoundMyFitness
A compound considered a fasting-mimicking drug that activates signaling pathways similar to fasting.
Supplements for Longevity & Their Efficacy | Dr. Peter Attia
Andrew Huberman
A famous sirtuin activator found in grape skin, initially thought to increase lifespan but found to have no consistent effect in rigorous ITP studies, except in a specific, bizarre mouse model.
204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.
Peter Attia MD
A compound mentioned in the context of interventions studied for their impact on muscle transcriptome, showing effects similar to metformin and acarbose.
Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)
Tim Ferriss
A plant compound chemically related to pterostilbene, but less bioavailable. Mentioned in comparison to pterostilbene.
239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)
Peter Attia MD
A compound mentioned in a study (not in humans, but in cattle) that caused significant changes in fiber type profile, specifically increasing slow-twitch fibers.
Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!
The Diary Of A CEO
A polyphenol found in red wine and other plants that activates sirtuins, shown to extend lifespan in mice, particularly when given intermittently.