Sirtuins

175 - The biology of aging, rapamycin, and other interventions that target the aging process

Peter Attia MD

A class of NAD+-dependent enzymes (mostly deacetylases) that play a role in aging. While activation is generally considered beneficial, evidence for strong lifespan extension in mice is mixed.

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

Peter Attia MD

A class of proteins involved in cellular metabolism and aging, their role in autophagy is not directly known by Eileen White.

#46–Chris Masterjohn, Ph.D.: Pathways to health and disease (NAD, sirtuins, methylation, choline...

Peter Attia MD

A class of enzymes that primarily repair DNA damage and require NAD+ as a substrate; often associated with aging and longevity.

The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

Tim Ferriss

A family of NAD+-dependent deacetylase proteins, initially discovered in yeast, that became popular in aging research due to early studies showing lifespan extension. Enthusiasm for their role as primary longevity nodes has waned.

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

A family of proteins believed to play a role in cellular health and aging, and targeted by Resveratrol. Research on their importance in aging remains controversial.

The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Andrew Huberman

A group of seven longevity genes/proteins that are key to cellular defense against aging, activated by low insulin levels, fasting, and certain supplements.

#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

Peter Attia MD

A class of molecules pioneering David Sinclair's field of aging research, known for their role in gene silencing, DNA repair, and response to energy and nutrients.

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41

Andrew Huberman

A class of proteins known to be activated during fasting, associated with cell repair and longevity.

#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD

Peter Attia MD

A family of genes discovered to control aging in yeast, maintaining gene silencing and responding to stress to repair DNA, requiring NAD+ for their activity.

#10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — living longer, healthier & turning back the clock

Peter Attia MD

A class of proteins involved in cellular regulation, first shown by Matt Kaeberlein to extend lifespan in yeast and C. elegans.

359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more

Peter Attia MD

A class of proteins that rely on NAD+ as a substrate in DNA repair; their field of study is considered complex and still being clarified despite controversy.

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Essentials

Andrew Huberman

216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

Peter Attia MD

A family of proteins often linked to NAD+ and aging, which Josh Rabinowitz prefers to set aside, focusing on the direct metabolic role of NAD+.

Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)

Tim Ferriss

Defensive pathways involved in aging, also stimulated by low insulin signaling.