The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

A former research biochemist and two-time New York Times best-selling author, who created LMNT.

Professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, focusing on biological mechanisms of aging to promote healthspan.

Co-director of the Dog Aging Project, who initiated discussions with Dr. Kaeberlein about studying aging in companion dogs.

A researcher at Einstein who has championed the TAME human clinical trial for Metformin.

A professor at MIT whose talk about understanding aging mechanisms using genetics and molecular biology inspired Dr. Kaeberlein to join his lab.

A long-time collaborator and friend of Dr. Kaeberlein, who leads the Aging Research Institute at National University Singapore and conducts broad, high-quality research in aging.

A famous chef who used Levels to find that walking a few hundred steps after meals significantly affected his glucose levels.

Chief Veterinary Officer of the Dog Aging Project, who contributed to the early ideas for the longitudinal study.

A researcher at Columbia University conducting a Rapamycin study on ovarian function and known for adapting cutting-edge technologies.

A repeat podcast guest and advisor for Levels.

A researcher whose lab published early studies on Resveratrol activating sirtuins and extending lifespan in yeast and mice, leading to significant media attention and the launch of the company Certris.

A researcher at Stanford who does cutting-edge research in stem cell biology and regeneration.

The largest longitudinal study of aging in companion dogs, founded and co-directed by Dr. Kaeberlein, focusing on genetic and environmental factors influencing aging in dogs and people, including a clinical trial with Rapamycin.

An NIH-funded center at the University of Washington, directed by Dr. Kaeberlein, dedicated to basic biology of aging research.

A smaller university where Dr. Kaeberlein received his undergraduate degrees in mathematics and biochemistry.

The institution where Yousin Suh conducts her research.

The institution where Anne Brunet conducts her research.

Dr. Kaeberlein is a professor and director of several research institutes at the University of Washington School of Medicine.

A program funded by the NIH to test interventions for their ability to extend lifespan in mice, serving as a 'gold standard' for reproducibility.

Where Dr. Kaeberlein began his graduate studies in 1998, initially intending to study structural biology before being drawn to aging research.

The institution where Brian Kennedy leads the aging research institute.

A drug being tested in the Dog Aging Project's clinical trial to slow and potentially reverse aspects of biological aging. It is known to reduce age-related sterile inflammation and reboot the immune system.

A sex hormone that extends lifespan in male mice, but its mechanism is currently a mystery.

One of the small molecules identified by the ITP for extending lifespan in mice.

A drug that showed large, though not widely replicated, lifespan extension effects in rodents and dogs in older studies, with research mysteriously stopping.

The most commonly prescribed anti-diabetic drug, heavily discussed for its potential longevity effects, and the subject of the TAME human clinical trial.

The clinical name for Rapamycin, primarily used to prevent organ transplant rejection and for some types of cancer.

A natural product that boosts a specific type of autophagy called mitophagy, helping restore metabolic function by breaking down damaged mitochondria. Early clinical trials suggest improvements in muscle function in older people.

A cofactor in thousands of metabolic reactions, crucial for central metabolism and cellular functions. Levels are thought to decline with age, and boosting them is a target for longevity interventions.

An anti-diabetic drug that has shown lifespan extension in mice, particularly in males, comparable to Rapamycin.

A natural product found in food, thought to enhance autophagy and shown to extend lifespan in some organisms and improve healthspan measures in mice. It's considered an autophagy booster.

A polyphenol from red wine, initially popularized as a sirtuin activator and purported longevity compound. Later research, including a meta-analysis, showed no consistent lifespan extension effect and it's considered a 'dirty drug'.

A class of molecules, including Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), thought to boost NAD+ levels for metabolic health benefits, though their efficacy and stability are debated.

An NAD+ precursor whose stability and bioavailability are debated, and whose lifespan-extending effects in mice have not been consistently reproduced by the ITP.

A natural product metabolite with some evidence of lifespan extension in mice, considered by Dr. Kaeberlein as a potential candidate for aging interventions.

An NAD+ precursor, similar to NR, with ongoing debates about its bioavailability and efficacy, and no lifespan studies in mice yet by the ITP.

A family of NAD+-dependent deacetylase proteins, initially discovered in yeast, that became popular in aging research due to early studies showing lifespan extension. Enthusiasm for their role as primary longevity nodes has waned.

A single-celled organism used in early genetic and molecular biology studies of aging in Leonard Guarente's lab.

The protein that Rapamycin inhibits; it promotes growth and is targeted by some bodybuilders. Its inhibition can paradoxically maintain muscle function better with age.

A nascent field with significant potential for aging interventions, though also subject to much noise and misinformation, aiming to reverse age-related epigenetic changes.

A human clinical trial examining Metformin's effects on age-related diseases, which has gained FDA agreement to consider a collection of age-related diseases as one endpoint.

A sugar-free electrolyte drink mix, formulated for electrolyte needs and popular with keto, low-carb, or paleo diets, or after endurance exercise. Known for its citrus salt flavor.

A company that makes continuous glucose monitors (CGMs) easy and accessible, providing real-time feedback on how foods affect glucose levels and health.

A company started by David Sinclair, focused on sirtuin activators like Resveratrol, which successfully marketed the longevity narrative surrounding these compounds.

A book by Tim Ferriss that discussed the health benefits of continuous glucose monitors over 10 years ago.

A New York Times best-selling book authored by Robb Wolf.

A New York Times best-selling book authored by Robb Wolf.