Drugs & Medications

Psychedelic compound discussed in the context of MRI studies; relates to the psilocybin/psilocin administration in subjects.

empathogen and stimulant

Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.

Lysergic acid diethylamide; discussed as part of psychedelic history and MKUltra-era discourse.

A legal substance used in therapy, intriguing due to its similar effects to psilocybin and MDMA despite being chemically different.

Psychoactive brew discussed in Brooklyn anecdote and personal experience; described as introspective and transformative.

Mentioned as a candidate drug for extending healthspan, part of the longevity interventions Jamie discusses.

ADHD medication, mentioned for its side effects but also highlighting the serious consequences of untreated ADHD.

Selective serotonin reuptake inhibitors, a class of antidepressant drugs, linked to a 75% increased risk of dementia in a meta-analysis of five studies.

A powerful opioid mentioned as a substance that addiction psychiatrist Dr. K helps patients overcome using meditation and other therapies.

A GLP-1 agonist drug used for weight loss and type 2 diabetes management.

Discussed in contrast to cocaine; its mechanism for keeping people awake is not classically stimulant-like and differs from cocaine's action.

Another psychedelic that has been explored for opioid use disorder, though studies have been less promising compared to psilocybin.

A medication for ADHD, described as a 'speed' (amphetamine), but noted for its effectiveness in increasing prefrontal cortex size and improving outcomes for children with ADHD.

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

Mentioned as an example of a common drug to which some people can have extreme individual responses, illustrating the variability in drug side effects.

chemical compound

Lipid-lowering medications that can increase the risk of type 2 diabetes by 50% in middle-aged and older women and may harm mitochondria.

chemical compound

GLP-1 receptor agonist used for diabetes and obesity; long-acting variants lead to sustained appetite suppression; approved 2005 (diabetes) and 2014 (obesity).

A psychedelic tryptamine, a serotonin agonist, known for inducing profound and rapid shifts in consciousness, leading to a sense of ego dissolution and intense, overwhelming experiences.

Mentioned as a psycho-stimulant but warned against due to its high addictive potential, especially in contrast to caffeine.

chemical compound

Mentioned as a major advance in healthcare that most people in the US have access to.

A stimulant medication that can be used to treat bulimia and binge eating disorder by increasing dopamine and norepinephrine.

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

An antidepressant that increases dopamine, used off-label to help men and women increase libido or sexual function.

pharmaceutical preparation of the element lithium, used primarily as a psychiatric medication for mood disorders

pharmaceutical product

Wikimedia disambiguation page

Another prostaglandin inhibitor, shown to have modest protective effects against autism-like symptoms in animal studies and a 13% relative risk reduction in the Swedish cohort study, which argues against acetaminophen's causal link.

Drug class discussed as potential brain health modulators; evidence discussed is preliminary.

Glucagon-like peptide-1 hormone; the natural signal that GLP-1 drugs aim to mimic to reduce appetite and regulate appetite-related hormones.

agents that inhibit Proprotein Convertase Subtilisin/Kexin Type 9, an enzyme that plays a role in the degradation of the LDL cholesterol receptors

chemical compound and antiviral drug

A benzodiazepine (Web 1.0 sleep medication) not considered great for sleep, as it primarily sedates rather than induces naturalistic sleep.

Another GLP-1 agonist medication similar to Ozempic, used for obesity.

A 5-alpha reductase inhibitor drug used to treat androgenic alopecia by inhibiting DHT production, but comes with potential side effects.

organic compound, often used as a street drug

chemical compound with antipyretic and pain relieving properties

chemical compound

chemical compound

A class of drugs considered interesting for geroprotection, potentially comparable to rapamycin and GLP-1 agonists. The speaker notes their effect in metabolically healthy individuals is less clear.

chemical compound

chemical compound, antidepressant medication

neuropeptide analogue of gastric inhibitory polypeptide

species of plant

chemical compound

immunomodulatory drug known for its ability to cause birth defects

chemical compound

viral disease affecting humans

hormone replacement medication

group of eight neurotoxic proteins produced by Clostridium botulinum

chemical compound

scientific article published on January 2007

pharmaceutical product

American brand of ibuprofen

pharmaceutical product

analgesic alkaloid (opioid)

chemical compound

pharmaceutical product

eradicated human disease

scientific article published in May 1971

active substance for the treatment of erectile dysfunction, prostate enlargement and pulmonary hypertension

chemical compound

therapy to elicit or amplify an immune response

antidepressant of the selective serotonin reuptake inhibitor (SSRI) class

chemical compound

mosquito-borne infectious disease

pair of enantiomers

chemical compound

species of plant

chemical compound

human hormone

pharmaceutical product

chemical compound

any of several combined vaccines against measles, mumps, and rubella

chemical compound

medication used in the management of alcohol and opioid use disorders

group of stereoisomers

substituted cathinone medication mainly for depression and smoking cessation

chemical compound

medication used to treat erectile dysfunction and pulmonary arterial hypertension

mammalian protein found in Homo sapiens

lipid-lowering medication

medication to decrease high blood uric acid levels

A medication (Category C) that 'can't be ruled out' for risk during pregnancy, but benefits for the mother may justify its use.

A lower-dose formulation of finasteride (1 mg/day) used to treat hair loss.

Selective Androgen Receptor Modulators mentioned as an alternative approach to building muscle that did not pan out as hoped by pharmaceutical companies, hinting at potential interest in Follistatin therapies.

An FDA-approved, centrally acting drug for hypoactive sexual desire disorder (HSDD) in premenopausal women, taken daily at bedtime. Works on serotinergic and dopaminergic receptors.

corticosteroid medication

pharmaceutical product

Antidepressants that can be used off-label to prolong ejaculatory time, though they may have side effects like reduced libido and ED.

chemical compound

Antihistamine medication

class of drug

selective serotonin reuptake inhibitor invented by Eli Lilly and Company in 1972

human hormone

constellation in the southern celestial hemisphere

scientific article published on 01 April 2008