Drugs & Medications

Psychedelic compound discussed in the context of MRI studies; relates to the psilocybin/psilocin administration in subjects.

empathogen and stimulant

Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.

Lysergic acid diethylamide; discussed as part of psychedelic history and MKUltra-era discourse.

A legal substance used in therapy, intriguing due to its similar effects to psilocybin and MDMA despite being chemically different.

Psychoactive brew discussed in Brooklyn anecdote and personal experience; described as introspective and transformative.

Mentioned as a candidate drug for extending healthspan, part of the longevity interventions Jamie discusses.

ADHD medication, mentioned for its side effects but also highlighting the serious consequences of untreated ADHD.

Selective serotonin reuptake inhibitors, a class of antidepressant drugs, linked to a 75% increased risk of dementia in a meta-analysis of five studies.

A powerful opioid mentioned as a substance that addiction psychiatrist Dr. K helps patients overcome using meditation and other therapies.

A GLP-1 agonist drug used for weight loss and type 2 diabetes management.

Discussed in contrast to cocaine; its mechanism for keeping people awake is not classically stimulant-like and differs from cocaine's action.

Another psychedelic that has been explored for opioid use disorder, though studies have been less promising compared to psilocybin.

A medication for ADHD, described as a 'speed' (amphetamine), but noted for its effectiveness in increasing prefrontal cortex size and improving outcomes for children with ADHD.

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

Mentioned as an example of a common drug to which some people can have extreme individual responses, illustrating the variability in drug side effects.

chemical compound

GLP-1 receptor agonist used for diabetes and obesity; long-acting variants lead to sustained appetite suppression; approved 2005 (diabetes) and 2014 (obesity).

chemical compound

Lipid-lowering medications that can increase the risk of type 2 diabetes by 50% in middle-aged and older women and may harm mitochondria.

A psychedelic tryptamine, a serotonin agonist, known for inducing profound and rapid shifts in consciousness, leading to a sense of ego dissolution and intense, overwhelming experiences.

Mentioned as a major advance in healthcare that most people in the US have access to.

Mentioned as a psycho-stimulant but warned against due to its high addictive potential, especially in contrast to caffeine.

chemical compound

A stimulant medication that can be used to treat bulimia and binge eating disorder by increasing dopamine and norepinephrine.

An SSRI antidepressant mentioned as a medication that interacts with melatonin ingestion.

Another prostaglandin inhibitor, shown to have modest protective effects against autism-like symptoms in animal studies and a 13% relative risk reduction in the Swedish cohort study, which argues against acetaminophen's causal link.

pharmaceutical product

Wikimedia disambiguation page

An antidepressant that increases dopamine, used off-label to help men and women increase libido or sexual function.

pharmaceutical preparation of the element lithium, used primarily as a psychiatric medication for mood disorders

Drug class discussed as potential brain health modulators; evidence discussed is preliminary.

agents that inhibit Proprotein Convertase Subtilisin/Kexin Type 9, an enzyme that plays a role in the degradation of the LDL cholesterol receptors

Glucagon-like peptide-1 hormone; the natural signal that GLP-1 drugs aim to mimic to reduce appetite and regulate appetite-related hormones.

Another GLP-1 agonist medication similar to Ozempic, used for obesity.

A benzodiazepine (Web 1.0 sleep medication) not considered great for sleep, as it primarily sedates rather than induces naturalistic sleep.

chemical compound and antiviral drug

A 5-alpha reductase inhibitor drug used to treat androgenic alopecia by inhibiting DHT production, but comes with potential side effects.

chemical compound

chemical compound with antipyretic and pain relieving properties

chemical compound

organic compound, often used as a street drug

A class of drugs considered interesting for geroprotection, potentially comparable to rapamycin and GLP-1 agonists. The speaker notes their effect in metabolically healthy individuals is less clear.

chemical compound, antidepressant medication

neuropeptide analogue of gastric inhibitory polypeptide

chemical compound

species of plant

chemical compound

immunomodulatory drug known for its ability to cause birth defects

chemical compound

viral disease affecting humans

hormone replacement medication

pharmaceutical product

group of eight neurotoxic proteins produced by Clostridium botulinum

chemical compound

scientific article published on January 2007

American brand of ibuprofen

pharmaceutical product

analgesic alkaloid (opioid)

chemical compound

pharmaceutical product

eradicated human disease

scientific article published in May 1971

chemical compound

therapy to elicit or amplify an immune response

active substance for the treatment of erectile dysfunction, prostate enlargement and pulmonary hypertension

chemical compound

antidepressant of the selective serotonin reuptake inhibitor (SSRI) class

mosquito-borne infectious disease

pair of enantiomers

pharmaceutical product

chemical compound

any of several combined vaccines against measles, mumps, and rubella

chemical compound

medication used in the management of alcohol and opioid use disorders

A diviner's sage containing Salvinorin A, which can produce dysphoric out-of-body experiences, studied by the host under clinical settings.

group of stereoisomers

A phosphodiesterase-5 inhibitor that blocks the enzyme phosphodiesterase, increasing cyclic GMP to maintain erections. It was originally developed as a blood pressure medication.

The antibiotic Dr. Snyder requested and took to treat suspected Lyme disease, which proved effective.

Human Chorionic Gonadotropin, a prescription drug used to increase fertility by stimulating testosterone and estrogen production.

substituted cathinone medication mainly for depression and smoking cessation

A GHRH peptide, often combined with a DAC (drug affinity complex) to extend its half-life.

A medication that reduces the risk of breast cancer by 50% over 10 years, offered to patients with a very high lifetime risk (north of 35%).

Antidepressants that can be used off-label to prolong ejaculatory time, though they may have side effects like reduced libido and ED.

An FDA-approved, centrally acting drug for hypoactive sexual desire disorder (HSDD) in premenopausal women, taken daily at bedtime. Works on serotinergic and dopaminergic receptors.

A medication (Category C) that 'can't be ruled out' for risk during pregnancy, but benefits for the mother may justify its use.

An opioid used as a treatment for opioid use disorder, sometimes prescribed to help individuals withdraw from kratom.

A statin where maximum efficacy is achieved at a low dose (e.g., 5mg), with higher doses primarily increasing side effects.

An antihistamine used in Tylenol PM to induce sleep, with concerns raised about forming a bad habit.

A painkiller mentioned in the context of Josh Peck's struggles with substance use, where drinking alcohol could lead to its use.

Non-steroidal anti-inflammatory drugs that can blunt exercise adaptations and should not be used routinely to get through training; acceptable for acute, severe pain.

A medication taken during fasting to manage rising uric acid levels, mentioned by the speaker.

Mentioned in the context of placebo studies, where subjects believing they received EPO experienced a large placebo effect on endurance performance.

A statin used in trials for children with heterozygous FH.

An autoimmune condition that Nick Cannon was diagnosed with at 32, specifically lupus nephritis, where his immune system attacks his kidneys.

An immunosuppressant medication, mentioned in the context of its use in hospitals for COVID-19 patients, which could potentially activate clinically silent parasitic infections.

A lower-dose formulation of finasteride (1 mg/day) used to treat hair loss.

The generic name for Prozac, a selective serotonin reuptake inhibitor (SSRI).

A mimetic for LH, used to stimulate Leydig cells to produce testosterone, preserving testicular volume and sperm production when used with exogenous testosterone. Was previously widely compounded but now restricted and costly.

Selective Androgen Receptor Modulators mentioned as an alternative approach to building muscle that did not pan out as hoped by pharmaceutical companies, hinting at potential interest in Follistatin therapies.