Acarbose

171- Longevity science: caloric restriction studies, aging biomarkers & possible longevity molecules

Peter Attia MD

An alpha-glucosidase inhibitor tested in the ITP, suggesting its benefits on longevity might be related to glucose kinetics rather than caloric intake.

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects

Andrew Huberman

A glucose disposal agent that works in the gut to prevent glucose absorption, found to have a survival benefit in the ITP not related to caloric restriction.

Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More

Tim Ferriss

A drug that prevents starch absorption, suggested in the ITP as a caloric restriction mimetic. It successfully extended life in mice, likely by blunting glucose spikes rather than reducing overall intake or weight.

The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

Tim Ferriss

An anti-diabetic drug that has shown lifespan extension in mice, particularly in males, comparable to Rapamycin.

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

An FDA-approved diabetes drug that blocks starch digestion and glucose absorption. In ITP, it extends lifespan in both sexes, especially males, likely by reducing glucose peaks, and is effective even when started in middle age.

#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+

Peter Attia MD

A medication capable of flatlining glucose levels after high-carbohydrate intake, considered by Peter Attia to be more potent than Metformin for glucose reduction.

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia MD

A drug referred to as undergoing studies similar to metformin for its effects on muscle transcriptome and aging.

324‒Metabolism, energy balance, and aging: the impact of diet, calorie restriction & macronutrients

Peter Attia MD

359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more

Peter Attia MD

A drug that blocks glucose absorption, identified by the ITP as targeting glucose metabolism and extending lifespan.