Cocaine

182 - Psychedelics & Recreational Drugs

Peter Attia MD

A Schedule 2 drug with high harm to the user, often leading to paranoia and addiction, and heightened cardiotoxicity when mixed with alcohol to form coca-ethylene. The guest considers it generally not worth the risk due to physical dangers and lack of trait-altering benefits.

Carl Hart: Heroin, Cocaine, MDMA, Alcohol & the Role of Drugs in Society | Lex Fridman Podcast #233

Lex Fridman

A drug discussed by Carl Hart, who posits that its negative effects are often exaggerated and that positive experiences are possible with responsible use in supportive environments.

How Your Brain’s Reward Circuits Drive Your Choices | Dr. Robert Malenka

Andrew Huberman

A psychoactive stimulant drug with high addictive liability, known for causing a rapid, powerful surge of dopamine.

The Science of Psychedelics for Mental Health | Dr. Robin Carhart-Harris

Andrew Huberman

A drug known to cause ego inflation by releasing dopamine, serving as a contrast to psychedelics which cause ego dissolution and affect serotonin.

An Ethnopharmacologist on Hallucinogens, Sex-Crazed Cicadas, and More | Dennis McKenna

Tim Ferriss

A harmful drug explicitly differentiated from the beneficial plant coca.

How to Become Resilient, Forge Your Identity & Lead Others | Jocko Willink

Andrew Huberman

A drug of abuse that provides sharp, but short-lived, increases in dopamine, followed by a drop below baseline, differing from the sustained dopamine increase from cold exposure.

#25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis

Peter Attia MD

One of the illicit drugs Scott Harrison used frequently during his nightlife promotion years, eventually quitting after his epiphany.

Master Your Sleep & Be More Alert When Awake | Huberman Lab Essentials

Andrew Huberman

A stimulant that is considered across the board bad due to its addictive and terrible effects.

Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping

Andrew Huberman

A Schedule II drug with very limited medical application, primarily as an anesthetic, but otherwise considered highly debilitating and addictive due to its impact on the dopamine system.

#76 – Kyle Kingsbury: Finding meaning, depression, and psychedelics

Peter Attia MD

Drug Kyle Kingsbury used during his period of substance abuse alongside alcohol and anti-anxiety pills, to manage depression.

LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Seattle, WA

Andrew Huberman

Mentioned as a potent substance that triggers significant dopamine release, making activities seem more interesting.

#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system

Peter Attia MD

A stimulant drug that lights up the brain's reward center, similar to how fructose consumption affects the brain.

Therapy, Treating Trauma & Other Life Challenges | Dr. Paul Conti

Andrew Huberman

Mentioned as chemically similar to stimulant ADHD medications, highlighting potential concerns.

Using Cortisol & Adrenaline to Boost Our Energy & Immune System Function

Andrew Huberman

A drug mentioned for its ability to increase learning in the short term, particularly due to increasing blood glucose, but it is advised not to take it.

243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito

Peter Attia MD

An illicit drug that is now frequently laced with fentanyl.

How to Increase Motivation & Drive

Andrew Huberman

A highly addictive substance that drastically increases dopamine release, leading to powerful cravings and a risk of compulsive behavior.

Psychedelics — Microdosing, Mind Enhancing Methods, and More | The Tim Ferriss Show (Podcast)

Tim Ferriss

A stimulant drug, research on its addiction treatment using psychedelics is showing initial positive results.

Advil, Aspirin, and Tylenol -- What's the difference?

Sabine Hossenfelder

A substance that acts as a local anesthetic, blocking pain signals by preventing nerve cells from firing.

Dopamine Expert: Doing This Once A Day Fixes Your Dopamine! What Alcohol Is Doing To Your Brain!

The Diary Of A CEO

A highly potent drug that causes strong dopamine release, shown to induce a rapid 'running frenzy' in rats, and a single re-exposure can lead to immediate relapse even after long abstinence.

ADHD & How Anyone Can Improve Their Focus | Huberman Lab Essentials

Andrew Huberman

220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.

Peter Attia MD

A stimulant drug whose neuroplasticity-inducing effects are cited as a reason it can become addictive, highlighting that neuroplasticity alone does not guarantee therapeutic benefit.