Arginine
An older nitric oxide precursor that has fallen out of favor due to bioavailability issues and potential side effects like cold sores; used for blood pressure.
Common Themes
Videos Mentioning Arginine
Dr. Andy Galpin: The Optimal Diet, Supplement, & Recovery Protocol for Peak Performance
FoundMyFitness
An older nitric oxide precursor that has fallen out of favor due to bioavailability issues and potential side effects like cold sores; used for blood pressure.
Developing a Rational Approach to Supplementation for Health & Performance | Huberman Lab Podcast
Andrew Huberman
A supplement with some, albeit weak, literature suggesting it can further elevate growth hormone levels when taken prior to bedtime, especially when fasted.
2020's Most Notable Research (with guests Eric Helms and Mike Zourdos) - Episode 51
Stronger By Science
A supplement reviewed in a meta-analysis where recalculations showed different, often non-significant, results from the original publication.
Science of Muscle Growth, Increasing Strength & Muscular Recovery
Andrew Huberman
An amino acid that, along with citrulline, can improve performance for long bouts of exercise by promoting vasodilation and increased blood flow, but may increase cold sore outbreaks.
How to Control Your Metabolism by Thyroid & Growth Hormone
Andrew Huberman
An amino acid that can substantially increase growth hormone levels and dilate blood vessels. Effective doses range from 3-10 grams, but more than 9 grams can blunt effects, and high oral doses can cause GI disturbance. Exercise and arginine supplementation don't have synergistic effects on GH increases.
205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)
Peter Attia MD
An amino acid that is a direct substrate for nitric oxide but is mostly extracted by splanchnic tissues, making citrulline more bioavailable for increasing nitric oxide levels.
Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)
Stronger By Science
A meta-analysis claimed large effects on aerobic performance (0.84) and smaller effects on anaerobic performance (0.24), but the analysis had calculation issues. Due to poor bioavailability, citrulline is recommended over arginine for nitric oxide production.
224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.
Peter Attia MD
An amino acid mentioned for its role in nitric oxide production and vasodilation.