Saccharin

The Fat Burning Expert: The REAL Reason You’re Not Losing Belly Fat (and How To Fix It Fast!)

The Diary Of A CEO

An artificial sweetener, known as the 'little pink packet', which has a poor track record for impairing glucose control and causing weight gain, and is almost commercially extinct.

The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Andrew Huberman

An artificial sweetener that has been shown to disrupt the gut microbiome in certain cases, but is rarely used anymore.

#87—Rick Johnson, MD: Fructose—the common link in hypertension, insulin resistance, T2D, & obesity?

Peter Attia MD

An artificial sweetener that has been associated with bladder tumors in mice, highlighting potential safety concerns.

Nutrients For Brain Health & Performance | Huberman Lab Podcast #42

Andrew Huberman

A type of artificial sweetener mentioned in the context of gut microbiome disruption, though the specific effects vary depending on the sweetener type.

The Science of Eating for Health, Fat Loss & Lean Muscle | Dr. Layne Norton

Andrew Huberman

An artificial sweetener that along with sucralose showed changes in blood glucose and microbiome in a recent human study.

E93: Twitter whistleblower, cloud security vulnerabilities, student debt forgiveness & more

All-In Podcast

An artificial sweetener that, along with sucralose, was found to adversely affect blood glucose control and alter the gut microbiome.

Metabolic Rate, Artificial Sweeteners, Electromyography, and Non-Failure Training (Episode 35)

Stronger By Science

An artificial sweetener possibly discovered by a chemistry student tasting a sample, and one of a few that might alter the gut microbiome to some degree.

How to Enhance Your Gut Microbiome for Brain & Overall Health

Andrew Huberman

An artificial sweetener shown in mouse models to disrupt the gut microbiome, though human data are inconclusive.

How Foods and Nutrients Control Our Moods

Andrew Huberman

A specific artificial sweetener shown in a Nature study to disrupt the gut microbiome negatively by promoting unfavorable bacteria, rather than killing the microbiome.

Aspartame: The Surprisingly Interesting Science and History (Episode 116)

Stronger By Science

Gut Health with Dr. Gabrielle Fundaro (Episode 40)

Stronger By Science

An artificial sweetener that may interact with the microbiota, though human data is minimal and effects observed at very high intake levels and in mouse models.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

An artificial sweetener shown in mouse and human studies to alter the gut microbiome, increasing bacteria that extract more glucose and store fat, and decreasing glucose tolerance.