All Things Ketamine — The Most Comprehensive Podcast Episode Ever with Dr. John Krystal

A handbook to which Henry Krystal contributed a chapter, quoted by Tim Ferriss.

The first antidepressant, discovered in 1957, which prevented the breakdown of norepinephrine and serotonin, chemicals implicated in depression.

An opioid pain medication that can have a fatal interaction with MAO inhibitors.

A potent psychedelic compound found in plants like Psychotria viridis, made orally available by MAO inhibitors in Ayahuasca.

A class of antidepressants discovered after MAOIs, acting through similar mechanisms.

A monoamine oxidase inhibitor found in Banisteriopsis caapi, part of Ayahuasca, known to have therapeutic effects and increase BDNF.

Antidepressants like Prozac, developed in the 1980s, that specifically block serotonin reuptake.

A psychedelic brew containing harmine (MAOI) and NN-DMT from Psychotria viridis, which has traditional preparatory diets that align with MAOI contraindications.

Dr. John Krystal's father, a psychiatrist and psychoanalyst who survived the Holocaust and developed the concept of 'Survivor Syndrome,' contributing to the diagnosis of PTSD.

The guest expert, Robert L. McNeil Jr. Professor of Translational Research, Chair of Psychiatry at Yale University, and Chief of Psychiatry at Yale New Haven Hospital. He is a leading expert in alcoholism, PTSD, schizophrenia, and depression, known for leading the discovery of ketamine's rapid antidepressant effects.

Chairman of the Department of Psychiatry at Wayne State University, who influenced Henry Krystal and after whom Dr. John Krystal is named.

Mentioned as having analyzed John Dorsey.

A colleague of Henry Krystal who, along with Krystal, developed the concept of 'Survivor Syndrome'.

The host of the Tim Ferriss Show, who has experienced chronic and severe depression and has personal interest in ketamine treatments.

Mentioned as another contributor to the understanding of trauma, alongside Henry Krystal's work.

Where Henry Krystal received a scholarship for college and later medical school.

A newspaper from which Tim Ferriss quoted a section about Henry Krystal.

Developed by Henry Krystal and Bill Niederland, an idea about the psychological consequences of trauma that was a cornerstone for the diagnosis of PTSD.

The Greek Hippocratic doctors' term for a fundamental negative mode of being, connected to black bile, which describes a severe form of depression.

A potentially serious medical condition caused by excessive serotonin levels, which can be a risk with MAOIs if combined with certain foods or other drugs.

A disorder whose diagnosis was significantly influenced by the work of Henry Krystal and Bill Niederland.

A gold-standard treatment for severe depression, often effective when other medications fail, but with decreasing access in the U.S.

A concentration camp mentioned in the context of Henry Krystal's Holocaust survival.

A concentration camp mentioned in the context of Henry Krystal's Holocaust survival.

A clinical-stage biotechnology platform co-founded by Dr. Krystal, developing next-generation ketamine and psychedelic therapeutics.

A compound found in aged cheese and wines that can cause dangerous blood pressure increases when combined with MAO inhibitors.