Metformin
Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.
Research
Expert discussions of Metformin across 92 podcasts.
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Common Themes
Videos Mentioning Metformin
410 ‒ The biology of pregnancy: physiologic adaptation, childbirth, and long-term maternal health
Peter Attia MD
A medication considered fairly safe and potentially helpful in pregnancy for gestational diabetes, but insulin is generally preferred as first-line.
I Did Mushrooms for Science, Pt. 2
Bryan Johnson
A common medication used to improve glycemic control, mentioned as a comparison to the effects of psilocybin on blood sugar.
E110: 2023 Bestie Predictions!
All-In Podcast
Mentioned for its incredible benefits in cell regeneration, longevity, and glucose management, even when taken prophylactically, especially given the prevalence of pre-diabetes in the American diet.
#500! KevKev TimTim TalkTalk on Dragon Slaying, Lessons Learned, Viagra, and Assorted Nonsense
Tim Ferriss
A drug sometimes considered for longevity, which Tim Ferriss does not currently take but might consider in the future.
Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda
Andrew Huberman
A drug that activates 'AMP kinase,' mimicking a fasting state and potentially increasing longevity.
Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)
Tim Ferriss
A drug sometimes discussed in relation to mTOR and lifespan extension.
Dr. Dominic D'Agostino on Fasting, Ketosis, and The End of Cancer
Tim Ferriss
A drug used by type 2 diabetics to decrease hepatic gluconeogenesis and is being researched for cancer prevention and treatment due to its activation of AMPK and calorie restriction mimicking effects.
Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!
The Diary Of A CEO
A drug that has been shown to interfere with muscle growth in weightlifters by affecting mitochondria; Dr. Sinclair suggests pulsing it for longevity benefits.
Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
All-In Podcast
A drug commonly used for managing blood glucose levels, mentioned in the context of longevity interventions. It is contrasted with the metabolic reset observed from psilocybin.
Q&A with Tim — How to Get Unstuck, Resilience in Hard Times, Tools for Brain Health, and More
Tim Ferriss
Mentioned as a potential intervention for managing elevated A1c levels.
The Brain Doctor That Figured Out The Cause Of Dementia - Dr. David Perlmutter
The Diary Of A CEO
A diabetes pill being studied in the ADS Smart Trial for Alzheimer's, known to mimic many effects of exercise and improve mitochondrial function. However, its routine use in healthy adults is problematic due to potential downsides.
AI Just Compressed 160 Years of Aging Research — Here's What They Found | Dr. David Sinclair
Tom Bilyeu
A prescription glucose-lowering medicine, taken by Dr. Sinclair to manage blood glucose mainly due to family history of diabetes. He found US versions cause stomach upset, preferring an enteric-coated version from Australia or Berberine.
Why You’re Tired, Unmotivated, and Unfocused - Dr. Andrew Huberman (4K)
Chris Williamson
A drug that Andrew Huberman does not take, due to its effects on blood sugar; Berberine is described as 'poor man's Metformin'.
Fatty Liver Expert: Stop Eating These “Healthy” Foods - Dr David Unwin
The Diary Of A CEO
The most commonly used drug for Type 2 Diabetes, which Dr. Unwin was incentivized to prescribe even though he later found lifestyle changes could be more effective.
How To Slow Biological Aging With a Multivitamin, Vegetables, & Omega-3 | Dr. Steve Horvath
FoundMyFitness
An intervention for which some studies suggest it affects epigenetic age, though the effect is noted to be much weaker than medical interventions for specific conditions.
Dr. Andrew Huberman — Peptides, Performance, and Protocols
Tim Ferriss
A drug mentioned in the context of trials involving GH, typically taken with 1-2 IUs of GH per night.
402 ‒ NMR blood analysis: how mortality risk and more can be assessed from a single blood sample
Peter Attia MD
A medication used for diabetes prevention and treatment, shown to reduce LPIR scores, though less significantly than lifestyle changes.
403 ‒ Peptides: separating scientific promise from marketing hype
Peter Attia MD
Cited as a natural molecule that was modified and patented, demonstrating pharmaceutical monetization strategies.
“Age Reversal Is Coming.” Everything You Need To Know - Dr David Sinclair
Chris Williamson
A drug mentioned as a potential longevity intervention.
407 ‒ Preventing cardiovascular and Alzheimer’s disease: lowering LDL early, APOE4, and more
Peter Attia MD
Mentioned as an example of an FDA-approved drug whose exact mechanism of action is not fully known.