Rapamycin

David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189

Lex Fridman

A drug that some people are experimenting with to counteract the effects of meat on long-term health by inhibiting the mTOR pathway, potentially extending lifespan.

Dr. Andrew Huberman — A Neurobiologist on Sleep, Performance, and Anxiety | The Tim Ferriss Show

Tim Ferriss

A drug mentioned in the context of canine research and longevity by Tim Ferriss.

#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+

Peter Attia MD

A drug known for its lifespan-extending effects across various organisms and its impact on senescent cells, discussed in the context of optimizing dosage and frequency for longevity.

Dr. Peter Attia, MD — Fasting, Metformin, Athletic Performance, and More | The Tim Ferriss Show

Tim Ferriss

A drug named after Rapa Nui, which they may discuss in relation to longevity.

Q&A With Tim — On Wealth, Legacy, Grief, Lyme Disease, and More | The Tim Ferriss Show

Tim Ferriss

A drug of interest to Tim Ferriss for longevity purposes, though challenging to determine human dosage.

E26: State of Venture Capital, plus fan questions on longevity, decentralization & quantum computing

All-In Podcast

Mentioned as a compound that can mimic fasting on a cellular level for longevity.

"Anti-Aging" Drugs — NAD, metformin, & rapamycin | The Peter Attia Drive Podcast (Ep 207, AMA 35)

Peter Attia MD

A geroprotective molecule discussed as a primary topic.

How to Ask Better Questions, Take Better Risks, and More! | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug that Tim Ferriss does not currently use but might incorporate in the future for longevity/autophagy protocols.

357 ‒ A new era of longevity science: models of aging, rapamycin trials, biological clocks, & more

Peter Attia MD

Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

FoundMyFitness

A drug that blocks the mTOR pathway, discussed for its potential anti-aging effects but also associated with negative side effects like hyperglycemia and testicular degeneration.

Supplements for Longevity & Their Efficacy | Dr. Peter Attia

Andrew Huberman

A medication that targets mTOR, taken by Peter Attia for its geroprotective effects, demonstrating life extension in model organisms.

How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon

Andrew Huberman

A drug that inhibits mTOR, being explored by some as a way to extend lifespan, but poses a contradiction with resistance training which stimulates mTOR.

222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

Peter Attia MD

A drug frequently discussed for its potential geroprotective effects, working as an mTOR inhibitor. Its dosing and timing are still complex even in controlled settings.

216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

Peter Attia MD

A medication Peter Attia takes, acknowledging it has good but imperfect evidence, contrasting with his reluctance to take NAD+ precursors due to lack of compelling human data.

205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)

Peter Attia MD

An mTOR inhibitor, used as a cancer treatment drug, but not necessarily a good idea for cancer prevention due to potential side effects and its complex action on mTOR complex 1 and 2.

202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes

Peter Attia MD

A drug that will be discussed in a future AMA episode with Matt Kaeberlein regarding its role in longevity alongside Metformin and NAD+ precursors.

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia MD

A well-known gerotherapeutic agent, often compared with metformin, with strong evidence for longevity extension in animal models, particularly through the ITP studies.

Outlive: The Science and Art of Longevity — Dr. Peter Attia

Tim Ferriss

Mentioned as a drug that can be important for longevity, alongside APO B control and metformin.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

A compound shown to affect lifespan in animals, mentioned in comparison to Metformin.

#500! KevKev TimTim TalkTalk on Dragon Slaying, Lessons Learned, Viagra, and Assorted Nonsense

Tim Ferriss

A drug sometimes considered for longevity, which Tim Ferriss does not currently take but might consider in the future.

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

Andrew Huberman

A drug that reduces 'mTOR activation,' which also mimics aspects of the fasting state and can extend lifespan in mice.

Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)

Tim Ferriss

An immune-suppressant drug that shuts down mTOR; Art De Vany advises against its chronic use due to potential negative effects on immunity and growth.

Why You’re Tired, Unmotivated, and Unfocused - Dr. Andrew Huberman (4K)

Chris Williamson

A drug that targets mTOR and mimics fasting, showing extension of life in animal studies. Peter Attia is bullish on it, but Andrew Huberman does not take it due to insufficient human data.

All Things Ketamine — The Most Comprehensive Podcast Episode Ever with Dr. John Krystal

Tim Ferriss

A drug that blocks the mTOR pathway, and in a study with ketamine, surprisingly extended its antidepressant effects, possibly by preventing microglia from "gobbling up" new synapses.