Triparanol
An early drug from the 1950s that lowered cholesterol by inhibiting an enzyme, but resulted in a higher incidence of heart attacks due to increased desmosterol levels, making it more atherogenic.
Videos Mentioning Triparanol
#23–Tom Dayspring Part IV of V: statins, Zetia, PCSK9 inhibitors, niacin, cholesterol & the brain
Peter Attia MD
An esoteric drug that inhibited delta-24 desaturase in the cholesterol synthetic pathway, lowered cholesterol, but was pulled off the market due to side effects like atherosclerosis and cataracts, highlighting the complexity of drug development.
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Peter Attia MD
An early lipid-lowering drug introduced around 1950 that lowered total cholesterol but was later pulled off the market due to increased cardiovascular mortality, likely linked to increased desmosterol levels.
235‒Training principles for mass & strength, changing views on nutrition, & creatine supplementation
Peter Attia MD
An older drug from the 1960s that was approved for lowering cholesterol but later withdrawn due to increasing cardiovascular events, possibly because it caused an accumulation of desmosterol.
Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
FoundMyFitness
An early drug from the 1950s that lowered cholesterol by inhibiting an enzyme, but resulted in a higher incidence of heart attacks due to increased desmosterol levels, making it more atherogenic.