PD-1
Another checkpoint protein on T-cells, similar to CTLA-4, that inhibits immune response; drugs targeting PD-1 (like Keytruda) are also a form of checkpoint inhibitor.
Common Themes
Videos Mentioning PD-1
181 - Viewing cancer through an evolutionary lens: a radically different approach to treatment
Peter Attia MD
A checkpoint receptor, mutations in which make patients highly responsive to anti-PD-1 drugs like Keytruda.
177 - The development of cancer immunotherapy and its promise for treating advanced cancers
Peter Attia MD
An inhibitory molecule on the surface of lymphocytes; targeting it with antibodies (checkpoint inhibitors) removes brakes on the immune system, allowing T-cells to react more aggressively.
#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19
Peter Attia MD
Programmed death-1, a checkpoint inhibitor found on exhausted T-cells (CD4 and CD8) that accumulate with age, and which Rapamycin analogs can decrease.
#32–Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and writing
Peter Attia MD
A checkpoint inhibitor target in immunotherapy, recognized with a Nobel Prize for its role in cancer treatment.
286‒Journal club with Andrew Huberman: light exposure on mental health & an immunotherapy for cancer
Peter Attia MD
Another checkpoint protein on T-cells, similar to CTLA-4, that inhibits immune response; drugs targeting PD-1 (like Keytruda) are also a form of checkpoint inhibitor.
202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes
Peter Attia MD
A programmed death receptor on immune cells, targeted by checkpoint inhibitor drugs to block immune system 'brakes,' helping the immune system attack cancer cells.
Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer
Andrew Huberman
Another checkpoint receptor on T-cells, targeted by newer immunotherapy drugs like Pembrolizumab, which has shown even greater efficacy than CTLA-4 inhibitors.