Mendelian randomization

This Supplement Could Cut Your Dementia Risk By 40%

FoundMyFitness

A method using genetics to examine how environmental factors, like Vitamin D levels influenced by genes, can affect outcomes such as dementia risk.

Cardiovascular disease & why we should change the way we assess risk | The Peter Attia Drive Podcast

Peter Attia MD

A genetic epidemiological method that uses genetic variants as instrumental variables to assess the causal effect of a modifiable exposure on disease outcome, allowing for closer inference to causality than traditional observational studies.

Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More

Tim Ferriss

An elegant tool that infers causality by identifying genes responsible for traits, then modeling outcomes based on the presence or absence of that genetic trait, bypassing observational biases.

#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it

Peter Attia MD

A method using genetic instruments to create study designs that are more equivalent to randomized trials, offering more credible estimates than pure observational evidence.

The Science of Eating for Health, Fat Loss & Lean Muscle | Dr. Layne Norton

Andrew Huberman

A research method that uses natural genetic variation as a form of natural randomization to study lifetime exposure effects, especially for outcomes like heart disease and cholesterol.

#66 – Vamsi Mootha, MD: Aging, T2D, cancer, dementia, Parkinson’s—do all roads lead to mitochondria?

Peter Attia MD

A research method used to infer causality from observational data, by using genetic variants as a natural form of randomization akin to a drug trial.

Micronutrients for Health & Longevity | Dr. Rhonda Patrick

Andrew Huberman

A scientific study design using common genetic variations (SNPs) to assess causal relationships between a modifiable risk factor (like Vitamin D levels) and disease outcomes, reducing bias.

Fasting, well-balanced diets, alcohol, exercise, assessing cardiovascular health (AMA 68 Sneak Peek)

Peter Attia MD

235‒Training principles for mass & strength, changing views on nutrition, & creatine supplementation

Peter Attia MD

A research method using genetic variations to infer causal relationships between risk factors and health outcomes, described as a 'lifetime randomized control trial' for understanding long-term exposure effects.

229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB

Peter Attia MD

A research methodology that uses genetic variants to infer population-level causal relationships between exposures and outcomes, helping to overcome confounding in observational studies.

210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.& Peter Attia, M.D.

Peter Attia MD

A type of genetic analysis that links genotype to phenotype, used to bridge observational epidemiology and clinical trials to infer causal relationships.