Leptin

How Fructose Drives Metabolic Disease | Rick Johnson, M.D.

Peter Attia MD

A hormone produced in fat cells that signals satiety to the brain. Fructose consumption can lead to leptin resistance, causing animals (and humans) to eat more despite adequate fat stores.

How Sugar & Processed Foods Impact Your Health | Dr. Robert Lustig

Andrew Huberman

A hormone produced by fat cells that signals satiety to the brain; its signaling is blocked by high insulin, leading to increased hunger and reduced movement.

#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications

Peter Attia MD

A hormone involved in appetite and metabolism, mentioned in the context of lipodystrophy where it may not be working effectively.

All Things Sleep (Weight Gain, Alzheimer’s Disease, Caffeine, and More) — Dr. Matthew Walker

Tim Ferriss

A hormone that signals satiety to the brain, telling it not to eat. Sleep deprivation causes its levels to drop.

167 - Gary Taubes: Bad science and challenging the conventional wisdom of obesity

Peter Attia MD

A hormone identified by Jeffrey Friedman, often interpreted as a satiety hormone, but whose role in obesity is seen differently by Gary Taubes as related to hyperinsulinemia.

The Top 7 Belly Fat Burning Hacks For 2024 That Are PROVEN To Work!

The Diary Of A CEO

#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

Peter Attia MD

A hormone primarily produced by adipose tissue that plays a critical role in regulating body weight and appetite, initially discovered as a missing factor in obese mice.

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41

Andrew Huberman

A hormone produced by body fat that signals to the brain, playing a crucial role in puberty and maintaining ovulation in menstruating women.

Coaching Cues, Fat-Free Mass Index, Non-Responders, and Dr. Brad Dieter (Podcast Episode 10)

Stronger By Science

Hormone involved in body fat regulation; people who gain and lose a lot of weight may show sustained leptin resistance.

The Glucose Expert: The Only Proven Way To Lose Weight Fast! Calorie Counting Is A Load of BS!

The Diary Of A CEO

An energy sufficiency hormone made in fat cells, signaling to the brain when enough energy is stored; insulin blocks leptin, leading to hunger and reduced physical activity.

324‒Metabolism, energy balance, and aging: the impact of diet, calorie restriction & macronutrients

Peter Attia MD

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)

Stronger By Science

Mentioned in the context of extreme interventions for hypothalamic amenorrhea, where injecting leptin alongside dietary and exercise modifications showed highly variable restoration of the menstrual cycle.

Fructose, Knee Sleeves, Weight Loss Variability, and James Krieger (Episode 30)

Stronger By Science

A hormone mentioned as a regulator of fat metabolism, possibly more important than insulin.

215 - The gut-brain connection | Michael Gershon, M.D.

Peter Attia MD

A hormone that can signal to the brain, affecting the urge to eat. It is transported across the blood-brain barrier to affect the central nervous system directly.

212 - The Neuroscience of Obesity | Peter Attia, M.D. & Stephan Guyenet, Ph.D.

Peter Attia MD

A hormone produced by adipocytes in proportion to body fat mass, playing a key role in the lipostat and satiety signaling in the brain. Its discovery in 1994 led to a scientific bonanza.

Noah Kagan Interview (Full Episode) | The Tim Ferriss Show (Podcast)

Tim Ferriss

A hormone involved in appetite and metabolism regulation, mentioned in the context of biochemical reasons leaning out helps bulking.