Melatonin
Hormone signaling light exposure; endogenous production varies with seasons; supplements are often supra-physiological and require caution, especially during pregnancy.
Research
Expert discussions of Melatonin across 60 podcasts.
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Common Themes
Videos Mentioning Melatonin
Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)
Tim Ferriss
A supplement taken by Art De Vany for its protective and stress-resistant properties, not just as a sleep aid, often at higher doses (5-10mg).
Human Biology is About to Change Forever - Bryan Johnson (4K)
Chris Williamson
Discussed in relation to proper dosing for sleep, with Bryan Johnson taking a very small amount (300 mcg) to offset pineal gland calcification, contrasting with common large doses.
How Women Can Improve Their Fertility & Hormone Health | Dr. Natalie Crawford
Andrew Huberman
A hormone supplemented at low doses (1-3mg) before bed can improve fertility outcomes and egg quality, especially in cases of chronic inflammation.
Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity
a16z
A hormone that regulates sleep-wake cycles, often used as a supplement for sleep.
Understanding & Controlling Aggression | Huberman Lab Essentials
Andrew Huberman
A hormone that is reduced in long days with sunlight and increases in short days, influencing states of quiescence and potentially aggression.
How to Reclaim Your Brain in 2026 - Dr Andrew Huberman (4K)
Chris Williamson
A hormone associated with sleep, which is at its highest levels when cortisol is lowest during early sleep. Supplementation is generally not recommended in large amounts due to potential suppression of the hypothalamic-gonad axis.
Why You’re Tired, Unmotivated, and Unfocused - Dr. Andrew Huberman (4K)
Chris Williamson
A hormone released from the pineal gland that contributes to sleepiness. Bright light exposure, especially in the morning, can suppress melatonin levels.
“The Silent Collapse of the Mind: Inside Mental Exhaustion” | Jahona Umaraliyeva | TEDxIIAU
TEDx Talks
Discussed as a sleep supplement that should not be taken without professional prescription due to potential side effects like dependency and nightmares.
Essentials: Sleep Toolkit for Optimizing Sleep & Sleep-Wake Timing
Andrew Huberman
A hormone naturally released in the evening that promotes sleepiness. The speaker advises caution with excessive supplemental melatonin dosages compared to endogenous production.
Something Is Very Wrong With Modern Life - Arthur Brooks
Chris Williamson
A hormone important for sleep regulation, whose production can be disrupted by looking at phones late at night.
Dante Livestream #9 (Wednesday, June 24 10AM)
Predictive History
A molecule in the brain that, when boosted by certain chemicals like psilocin, allows one to see the underlying 'fractals' of reality, suggesting reality is more complex than typically perceived.
Dante #9: Hell Cantos 32-34, Purgatory Cantos 1-4
Predictive History
A molecule suggested as the neurological basis for psychedelic effects, by constraining perception and allowing one to see 'fractals' of reality.