L-2-hydroxyglutarate

Concept

A metabolite that accumulates when mitochondria are dysfunctional and NAD+ is low/NADH is high; its increase can cause neurodegeneration.

Mentioned in 1 video

Videos Mentioning L-2-hydroxyglutarate

#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

Peter Attia MD

A metabolite that accumulates when mitochondria are dysfunctional and NAD+ is low/NADH is high; its increase can cause neurodegeneration.