APOE4 gene
A genetic risk factor for Alzheimer's disease. Having one copy increases risk twofold, two copies tenfold. Its presence makes lifestyle choices, like avoiding alcohol and TBI, even more critical for brain health.
Common Themes
Videos Mentioning APOE4 gene

#48–Matt Walker, Ph.D., on Sleep (Part 2 of 3): Heart disease, cancer, causes of sleep disruption...
Peter Attia MD
A gene that significantly increases the risk for Alzheimer's disease. However, if an APOE4 carrier is normotensive (normal blood pressure), their risk is not necessarily increased. If they are hypertensive (high blood pressure), the risk is much higher, suggesting a gene by cardiovascular disease interaction.

Anti-Aging Expert: Missing This Vitamin Is As Bad As Smoking! The Truth About Creatine!
The Diary Of A CEO
A genetic risk factor for Alzheimer's disease. Having one copy increases risk twofold, two copies tenfold. Its presence makes lifestyle choices, like avoiding alcohol and TBI, even more critical for brain health.

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise
Peter Attia MD
A gene variant mentioned in the context of increased risk for Alzheimer's disease.

164 - Diagnosing, preventing, & treating Alzheimer’s disease, & life lessons from dementia patients
Peter Attia MD
A genotype that carries a higher risk for Alzheimer's disease, particularly for homozygotes, and can influence responses to cardiovascular medications. It's not diagnostic but indicates risk.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)
Tim Ferriss
A gene polymorphism identified to play a role in the context of a high-fat diet.

234 ‒ Chris Hemsworth on Limitless, longevity, and happiness
Peter Attia MD
A genetic variant that, when inherited from both parents (APOE4/4 genotype), significantly increases the risk of late-onset Alzheimer's disease.

Improve Vitality, Emotional & Physical Health & Lifespan | Dr. Peter Attia
Andrew Huberman
An isoform of the APOE gene strongly associated with an increased risk of Alzheimer's disease.