Caffeine
Stimulant discussed as increasing dopamine modestly and influencing receptor density; includes yerba mate as a related caffeine source.
Research
Expert discussions of Caffeine across 54 podcasts.
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Common Themes
Videos Mentioning Caffeine
Dr. Dominic D'Agostino on Fasting, Ketosis, and The End of Cancer
Tim Ferriss
A stimulant present in Utopian (cognitive enhancement agent), providing about 100 milligrams per serving.
How to Reclaim Your Brain in 2026 - Dr Andrew Huberman (4K)
Chris Williamson
A stimulant that chronic users build a tolerance to, so it doesn't significantly increase cortisol. Timing caffeine intake is important to avoid later cortisol spikes that disrupt sleep.
Why You’re Tired, Unmotivated, and Unfocused - Dr. Andrew Huberman (4K)
Chris Williamson
A commonly used drug (consumed by over 90% of adults) that blocks adenosine receptors, preventing sleepiness. Its effects wearing off lead to the 'caffeine crash' as accumulated adenosine binds to receptors.
Eating Hacks, Best Foods & High IQ Training Methods - Dr Mike Israetel
Chris Williamson
A stimulant that can marginally reduce appetite and improve mental clarity, but tolerance develops quickly, leading to rebound hunger.
Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett
Andrew Huberman
When applied topically to the scalp, caffeine can enter hair follicles and weakly crowd out androgens, potentially helping with hair loss.
Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
Andrew Huberman
A stimulant that can increase arousal and temporarily improve focus, but may dissociate subjective feeling of performance from actual performance, potentially leading to more errors on complex tasks.