Serotonin

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A neurotransmitter necessary for contentment (eudaimonia) and often depleted in individuals who feel lonely or irritable. It is the opposite of dopamine, signifying 'this feels good, I don't want or need anymore.'

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A neurotransmitter often mislabeled as a 'happiness chemical' but actually evolved as a metabolic regulator, influencing resource spending and energetics.

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A neurotransmitter that can also modify histones, influencing gene expression, as reported in a recent Nature paper.

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A neurotransmitter downregulated during REM sleep; too much serotonin (as with SSRIs) can weight cognition towards novelty, which might be maladaptive for trauma.

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A neuromodulator naturally made by the brain and body; psilocybin's active form, psilocin, closely resembles and mimics serotonin, primarily by activating the 5-HT2A receptor.

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A neuromodulator often associated with feelings of satiety, warmth, and satisfaction with immediate surroundings and possessions.

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A neuromodulator typically associated with feelings of happiness and contentment, with MDMA causing large increases in its levels, contributing to feelings of safety and comfort during MDMA-assisted psychotherapy.

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Andrew Huberman

A neuromodulator that influences mood and can lead to underestimation of time passed by slowing down the brain's frame rate.

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A neurotransmitter discussed in relation to gut health, mood elevation, and motivation.

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A neuromodulator that influences contentment with one's internal state, and is a target of many antidepressant medications.

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Anna Khachiyan, Ep. #017 of The Portal (with Eric Weinstein) - Reconstructing The Mystical Feminine.

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Peter Attia MD

A molecule that functions as a neurotransmitter and endocrine substance, with about 95% of the body's serotonin produced in the gut by enteroendocrine cells, and 2-3% in the brain. It's crucial for gut pain, nausea, development, and immune system interaction.