APOE4

381‒Alzheimer’s disease in women: how hormonal transitions impact the brain, new therapies, & more

Peter Attia MD

A well-known genetic risk factor for Alzheimer's disease discussed in midlife risk context.

#138-Lauren Rogen & Richard Isaacson MD: Alzheimer’s disease prevention—patient & doctor perspective

Peter Attia MD

The most common genetic risk factor for Alzheimer's disease. Having one or two copies of the e4 allele increases risk but does not guarantee the disease.

Supplements I’m Taking, Training for Mental Performance, AI Tools, Recovering from Surgery, and More

Tim Ferriss

A genetic marker that predisposes the speaker to Alzheimer's disease.

Health & Longevity: A Conversation with Peter Attia (Episode #328)

Sam Harris

A specific allele of the APOE gene, strongly associated with increased risk of Alzheimer's disease.

#147-Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s

Peter Attia MD

A genetic allele associated with an increased risk of Alzheimer's disease.

#35 – Nir Barzilai, M.D.: How to tame aging

Peter Attia MD

A gene variant strongly associated with an increased risk of Alzheimer's disease, but found in 100-year-old centenarians who did not develop dementia, suggesting protective genetic interactions.

257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies

Peter Attia MD

A genetic risk factor for Alzheimer's disease, whose status in August D was questioned.

#07 – Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know

Peter Attia MD

A variant of Apolipoprotein E that was protective against parasitic infections but increases Alzheimer's risk in modern times.

AMA #3: supplements, women’s health, patient care, and more (EP.26) | The Peter Attia Drive

Peter Attia MD

A genetic marker that increases risk for Alzheimer's disease, to be discussed in a future deep dive podcast.

244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

Peter Attia MD

A genetic risk factor for Alzheimer's disease, mentioned as an example of a less penetrant gene compared to Huntington's, raising complex ethical questions for gene editing.

Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer and More

FoundMyFitness

Genetics: how they impact disease risk, what you can do about it, testing & more [AMA 50 sneak peek]

Peter Attia MD

A specific variant of the APOE gene linked to Alzheimer's disease.

263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.

Peter Attia MD

Apolipoprotein E4 genotype, which has been studied in relation to concussion susceptibility, but currently lacks definitive supporting data for increased risk or specific outcomes.