AMP-activated protein kinase
An enzyme activated in starvation to raise energy levels. Uric acid inhibits AMPK, further blocking energy production and contributing to a low energy state, mimicking starvation.
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Videos Mentioning AMP-activated protein kinase
How Fructose Drives Metabolic Disease | Rick Johnson, M.D.
Peter Attia MD
An enzyme activated in starvation to raise energy levels. Uric acid inhibits AMPK, further blocking energy production and contributing to a low energy state, mimicking starvation.
#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications
Peter Attia MD
A protein activated by exercise, which causes a 'short-circuiting' of the insulin signaling pathway by inducing GLUT4 translocation independently of PI3-kinase.
#35 – Nir Barzilai, M.D.: How to tame aging
Peter Attia MD
A nutrient-sensing enzyme activated by Metformin, leading to downstream effects on mTOR and autophagy, and considered an exercise mimetic pathway.
Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda
Andrew Huberman
A sensor in cells that detects when cells are in a fasting state; activated by Metformin.