Orexin
A chemical in the brain crucial for wakefulness and feeding behaviors. A deficiency in orexin is linked to narcolepsy, and blocking its receptors (with DORAs) helps induce sleep by switching off wakefulness signals.
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Videos Mentioning Orexin
All Things Sleep (Weight Gain, Alzheimer’s Disease, Caffeine, and More) — Dr. Matthew Walker
Tim Ferriss
A wake-promoting chemical in the brain, deficient in narcolepsy. Its levels increase during sleep deprivation, possibly as an evolutionary mechanism to forage for food during perceived starvation.
Matt Walker: Sleep | Lex Fridman Podcast #210
Lex Fridman
A wake-promoting chemical whose increase during fasting explains subjective feelings of heightened alertness and reduced need for sleep.
Dr. Matt Walker: Protocols to Improve Your Sleep | Huberman Lab Guest Series
Andrew Huberman
A chemical in the brain crucial for wakefulness and feeding behaviors. A deficiency in orexin is linked to narcolepsy, and blocking its receptors (with DORAs) helps induce sleep by switching off wakefulness signals.