Orexin
A chemical in the brain crucial for wakefulness and feeding behaviors. A deficiency in orexin is linked to narcolepsy, and blocking its receptors (with DORAs) helps induce sleep by switching off wakefulness signals.
Videos Mentioning Orexin
All Things Sleep (Weight Gain, Alzheimer’s Disease, Caffeine, and More) — Dr. Matthew Walker
Tim Ferriss
A wake-promoting chemical in the brain, deficient in narcolepsy. Its levels increase during sleep deprivation, possibly as an evolutionary mechanism to forage for food during perceived starvation.
Matt Walker: Sleep | Lex Fridman Podcast #210
Lex Fridman
A wake-promoting chemical whose increase during fasting explains subjective feelings of heightened alertness and reduced need for sleep.
Dr. Matt Walker: Protocols to Improve Your Sleep | Huberman Lab Guest Series
Andrew Huberman
A chemical in the brain crucial for wakefulness and feeding behaviors. A deficiency in orexin is linked to narcolepsy, and blocking its receptors (with DORAs) helps induce sleep by switching off wakefulness signals.