Women's Health Initiative
long-term U.S. national health study that has focused on strategies for preventing the major causes of death, disability, and frailty in older women, specifically heart disease, cancer, and osteoporotic fractures
Common Themes
Videos Mentioning Women's Health Initiative
Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects
Andrew Huberman
A large, long-term national health study in the United States, mentioned as an example of a very expensive large-scale prospective randomized experiment.
#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy
Peter Attia MD
A randomized controlled trial in postmenopausal women, halted due to an increase in thromboembolic and cardiovascular events in the estrogen supplementation arm, reversing prior observational findings.
#42–Avrum Bluming, M.D. and Carol Tavris, Ph.D.: A compelling case for hormone replacement therapy
Peter Attia MD
A large-scale randomized clinical trial that significantly impacted the perception and prescription of hormone replacement therapy in 2002. It is critically analyzed throughout the podcast for its methodology and interpretation.
The Healthy Ageing Doctor: Doing This For 30s Will Burn More Fat Than A Long Run! Dr Vonda Wright
The Diary Of A CEO
A study on estrogen replacement that has been largely overturned, and Dr. Wright advises women to make their estrogen replacement decisions based on updated science, not outdated fear or myths.
Exercise, Nutrition, Hormones for Vitality & Longevity | Dr. Peter Attia
Andrew Huberman
A large clinical trial initiated in the 1990s to study hormone replacement therapy in postmenopausal women, widely criticized for flawed design and misrepresentation of results.
259 - Women's sexual health: Why it matters, what can go wrong, and how to fix it
Peter Attia MD
A large study whose findings were misinterpreted, leading to widespread fear and underutilization of hormone replacement therapy in women.
How to Navigate Menopause & Perimenopause for Maximum Health & Vitality | Dr. Mary Claire Haver
Andrew Huberman
A large-scale hormone therapy trial whose initial interpretation was problematic, leading to widespread demonization of estrogen therapy, but later re-analysis showed protective benefits when initiated at the right time.
AMA #3: supplements, women’s health, patient care, and more (EP.26) | The Peter Attia Drive
Peter Attia MD
A study that Peter Attia often criticizes for its problematic reporting of relative versus absolute risk in hormone replacement therapy.
224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.
Peter Attia MD
A study mentioned as part of the mixed literature on saturated fat and health outcomes.
Menstruation, Menopause, and Hormone Replacement Therapy for Women
Peter Attia MD
A large-scale study that significantly influenced the medical field's approach to hormone replacement therapy for women, with its preliminary results leading to widespread discontinuation of HRT due to perceived risks, which the speaker argues were misinterpreted.
The No.1 Menopause Doctor: They’re Lying To You About Menopause! Mary Claire Haver
The Diary Of A CEO
A significant study on hormone replacement therapy that led to widespread fear and misinformation, now largely debunked and reinterpreted.
253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results
Peter Attia MD
A large-scale randomized controlled trial investigating the effects of hormone replacement therapy and diet on chronic diseases in postmenopausal women.