COX-1
Concept
An enzyme irreversibly inhibited by aspirin, potentially making aspirin slightly worse for hypertrophy than NSAIDs, which primarily affect COX-2.
Mentioned in 2 videos
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Videos Mentioning COX-1

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)
Stronger By Science
An enzyme irreversibly inhibited by aspirin, potentially making aspirin slightly worse for hypertrophy than NSAIDs, which primarily affect COX-2.

Advil, Aspirin, and Tylenol -- What's the difference?
Sabine Hossenfelder
One of the two varieties of COX enzymes that NSAIDs block. Blocking COX-1 is associated with blocking pain but also with gastrointestinal and bleeding side effects.