COX-1

Concept

An enzyme irreversibly inhibited by aspirin, potentially making aspirin slightly worse for hypertrophy than NSAIDs, which primarily affect COX-2.

Mentioned in 2 videos

Videos Mentioning COX-1

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)

Season Finale: Tons of New Meta-Analyses and Q&A Catch-Up (Episode 46)

Stronger By Science

An enzyme irreversibly inhibited by aspirin, potentially making aspirin slightly worse for hypertrophy than NSAIDs, which primarily affect COX-2.

Advil, Aspirin, and Tylenol -- What's the difference?

Advil, Aspirin, and Tylenol -- What's the difference?

Sabine Hossenfelder

One of the two varieties of COX enzymes that NSAIDs block. Blocking COX-1 is associated with blocking pain but also with gastrointestinal and bleeding side effects.