CD38
A major driver of NAD+ decrease during aging, shown by Eduardo Chini's work. CD38 knockouts have stable NAD+ levels and live 15% longer.
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Videos Mentioning CD38
The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman
An enzyme identified by Eric Verdin that 'chews up' NAD+ as people get older, contributing to the decline in NAD+ levels.
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
Peter Attia MD
An enzyme that breaks down NAD+, most abundant on immune cells, suggesting an immune connection to NAD+ metabolism.
359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more
Peter Attia MD
A major driver of NAD+ decrease during aging, shown by Eduardo Chini's work. CD38 knockouts have stable NAD+ levels and live 15% longer.
216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.
Peter Attia MD
A protein thought to be designed to control NAD+ pathways, acting as a suppressor by breaking down extracellular NAD+ and NMN.