Clomiphene
A hormone used off-label for testosterone replacement in men. It stimulates LH and FSH production but can significantly raise desmosterol levels, posing a potential long-term risk similar to triparanol.
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Videos Mentioning Clomiphene
Improving Male Sexual Health, Function & Fertility | Dr. Michael Eisenberg
Andrew Huberman
A selective estrogen receptor modulator (SERM) that blocks estrogen receptors, leading to increased production of FSH and LH, thereby augmenting the body's own testosterone and potentially improving sperm production without the toxic effects of exogenous testosterone.
Tools for Hormone Optimization in Males | Dr. Kyle Gillett
Andrew Huberman
A selective estrogen receptor modifier (SERM) that blocks estrogen's action on the hypothalamus and pituitary, increasing testosterone. It has a unique side effect profile, including visual changes, and is not recommended for long-term testosterone optimization.
Exercise, Nutrition, Hormones for Vitality & Longevity | Dr. Peter Attia
Andrew Huberman
A fertility drug that stimulates FSH and LH secretion, used to indirectly increase testosterone in men with testicular reserve, but its use is restricted by Attia's practice due to elevated desmosterol levels.
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Peter Attia MD
A hormone used off-label for testosterone replacement in men. It stimulates LH and FSH production but can significantly raise desmosterol levels, posing a potential long-term risk similar to triparanol.