APOE
A gene that influences cholesterol metabolism and is a risk factor for Alzheimer's disease.
Common Themes
Videos Mentioning APOE
#18 – Richard Isaacson, M.D.: Alzheimer’s prevention
Peter Attia MD
A gene with three main types (E2, E3, E4) that significantly influences Alzheimer's risk. Isaacson clarifies that E4 carriers, while at higher risk, are not pre-destined for the disease, and genetic counseling for E4 status is controversial.
#21 – Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics and cholesterol regulation
Peter Attia MD
A protein transporter in the brain for lipids, distinct from ApoE in peripheral lipoproteins. It attaches to cholesterol and other sterols for transport within the central nervous system.
#22 – Tom Dayspring Part III of V: reverse cholesterol transport, CETP inhibitors, & apolipoproteins
Peter Attia MD
Apolipoprotein E, an important ligand for LDL receptors, which can enhance particle clearance when present on LDL particles.
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Peter Attia MD
A lipid-binding protein primarily made in the brain (by microglia) that transports lipids. It exists in isoforms (E2, E3, E4), with ApoE4 being a major genetic risk factor for Alzheimer's and ApoE2 being protective against Alzheimer's but associated with hyperlipidemia.
How to Quiet the Ruminative Mind and Avoid The Traps of Self-Help — Tim Ferriss
Tim Ferriss
A gene that influences cholesterol metabolism and is a risk factor for Alzheimer's disease.
210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.& Peter Attia, M.D.
Peter Attia MD
A gene with parallels to Lp(a), affecting Alzheimer's and cardiovascular disease risk, with different isoforms.