IBM 650
Don Knuth's first large-scale program was written for the IBM 650 in 1957 using decimal machine language. Stanford University, MIT, and Case Tech were early recipients of this machine. It had a memory of 2,000 ten-digit words, and debugging involved manually stepping through instructions.
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Videos Mentioning IBM 650

Donald Knuth: Programming, Algorithms, Hard Problems & the Game of Life | Lex Fridman Podcast #219
Lex Fridman
Don Knuth's first large-scale program was written for the IBM 650 in 1957 using decimal machine language. Stanford University, MIT, and Case Tech were early recipients of this machine. It had a memory of 2,000 ten-digit words, and debugging involved manually stepping through instructions.

Donald Knuth: Algorithms, Complexity, and The Art of Computer Programming | Lex Fridman Podcast #62
Lex Fridman
A mass-produced mainframe computer from 1957 with 2,000 words of memory (10 decimal digits plus a sign per word), known for being big and noisy but enabling many students to learn computing.