Yamanaka factors
set of four transcription factors (OCT4/POU5F1, SOX2, KLF4, c-MYC/MYC) used to reprogram somatic cells into induced pluripotent stem cells (iPSCs)
Common Themes
Videos Mentioning Yamanaka factors
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
Peter Attia MD
Four specific gene products that, when expressed in cells, can artificially induce a reset cellular state, similar to an embryonic state, with implications for youthful biology.
E137: Inflation cools, market rips, Ripple/MSFT beat regulators, NATO summit, cocktails of youth
All-In Podcast
Four chemicals that can reprogram cells to become stem cells, used in research for reversing aging but carry cancer risk.
E112: Is Davos a grift? Plus: globalist mishaps, debt ceilings, TikTok's endgame & more
All-In Podcast
Specific transcription factors that can induce pluripotency in somatic cells, related to epigenetics and reversing aging.
#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD
Peter Attia MD
A set of genes used in the reprogramming field to take an adult cell and convert it into a stem cell, effective for reversing cellular age.
E68: Trudeau invokes emergency powers, Bitcoin vs. government, Tiger Global's new strategy and more
All-In Podcast
A technology that can theoretically convert a person's own cells into stem cells for therapeutic use.
E65: VC markup dynamics, Russia/US tensions over Ukraine, Altos Labs raises $3B, Stripe mafia & more
All-In Podcast
The core of the science behind Altos Labs, these factors are used for cellular reprogramming in mice, showing age reversal without tumor formation.
Juan Carlos Izpisua Belmonte, Altos Labs | All-In Summit 2024
All-In Podcast
Four proteins used in cell reprogramming that can alter chromatin structure and potentially reverse aging.
Control Pain & Heal Faster with Your Brain
Andrew Huberman
Factors discovered by Yamanaka that can reprogram skin cells into neurons, offering potential for regenerative medicine but not yet an approved therapy.
Sam Altman: Getting Fired (and Re-Hired) by OpenAI, Agents, AI Copyright issues
All-In Podcast
Proteins that can reverse aging by tuning gene expression to make cells youthful, a process that AlphaFold 3 could simulate to find effective molecular combinations.
Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?
FoundMyFitness
Four transcription factors (OSKM) that can reprogram adult somatic cells into induced pluripotent stem cells.
Dave Ricks, CEO of Eli Lilly | The All-In Interview
All-In Podcast
Factors that can profoundly affect the epigenome, potentially influencing cell behavior and the aging process, a subject of fascination for Eli Lilly's R&D.
Marc Benioff | All-In Summit 2024
All-In Podcast
Four specific genes identified by Shinya Yamanaka that can reprogram ordinary skin cells into pluripotent stem cells.
222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.
Peter Attia MD
A set of four transcription factors (Oct3/4, Sox2, Klf4, c-Myc) used in cellular reprogramming to revert adult cells to an induced pluripotent stem cell state, and being explored for 'partial reprogramming' to reverse aging.
E113: DOJ tries to break up Google, vaccine questions, Ukraine escalation & more
All-In Podcast
These four proteins/molecules can reset gene expression in cells back to a stem cell-like state, demonstrating the potential to reverse aging in mice and offering a path for future therapeutics.
Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
All-In Podcast
Proteins used to induce pluripotency in cells, allowing them to become stem cells. The challenge lies in precise dosing to avoid cancerous transformations. New Limit is working on streamlining their discovery.