CAR T-cell therapy

Concept

A type of gene therapy where a patient's T-cells are genetically modified into 'weaponized' CAR T-cells to recognize and kill cancer cells, showing significant success in blood cancers like lymphoma and leukemia.

Mentioned in 4 videos

Videos Mentioning CAR T-cell therapy

177 - The development of cancer immunotherapy and its promise for treating advanced cancers

Peter Attia MD

A type of gene therapy where T-cells are engineered with a Chimeric Antigen Receptor (CAR) to recognize specific antigens on cancer cells. It was developed in Dr. Rosenberg's lab and became the first FDA-approved cell and gene therapy.

#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy

Peter Attia MD

Cell-based immunotherapy that has shown great promise in some people, particularly for lymphoma and pediatric acute lymphoblastic leukemia, but may have fleeting remissions in other conditions like multiple myeloma.

#121 – Azra Raza, M.D.: Why we’re losing the war on cancer

Peter Attia MD

A type of immunotherapy where a patient's T-cells are engineered to fight cancer, applauded for its sophisticated science but criticized by Dr. Raza for its inability to distinguish between normal and cancer cells, leading to severe side effects and limited applicability.

244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

Peter Attia MD