Aldose reductase
Concept
The rate-limiting enzyme in the polyol pathway that converts glucose to sorbitol. It is normally low in the liver but can be induced by high glucose, high uric acid, and increased serum osmolality.
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Videos Mentioning Aldose reductase
How Fructose Drives Metabolic Disease | Rick Johnson, M.D.
Peter Attia MD
The rate-limiting enzyme in the polyol pathway that converts glucose to sorbitol. It is normally low in the liver but can be induced by high glucose, high uric acid, and increased serum osmolality.
#87—Rick Johnson, MD: Fructose—the common link in hypertension, insulin resistance, T2D, & obesity?
Peter Attia MD
An enzyme that converts glucose to fructose, induced by high glucose levels, especially in obese individuals or diabetics, leading to endogenous fructose production even on a fructose-free diet.